Detail Information

Basic Information:


  VIRBase ID:  

HVID00009597

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1226-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0005577 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1226-3p
rs141645399 chr3:47849627    T/C
rs1431438028 chr3:47849618    T/C
rs1472927902 chr3:47849608    T/C
rs372320878 chr3:47849626    C/T
rs373981655 chr3:47849616    C/T
rs747968275 chr3:47849619    G/A
rs370902478 chr3:47849609    C/T
rs750372577 chr3:47849612    C/A
rs754955605 chr3:47849613    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1226-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1226-3p
Gemcitabine 60750 Drug interaction    RC00007606
5-Fluorouracil 3385 Drug interaction    RC00007604
Doxorubicin 31703 Drug interaction    RC00007605
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-1226-3p
5-Fluorouracil 3385       25356050
Doxorubicin 31703       25698578

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1226-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRanda
Support Database ViRBase

References:


[1]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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