Detail Information

Basic Information:


  VIRBase ID:  

HVID00009562

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-298 ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0004901 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-298
rs201036298 chr20:58818294    T/G
rs550848896 chr20:58818288    C/A
rs550848896 chr20:58818288    C/T
rs751823623 chr20:58818295    G/T
rs910750200 chr20:58818287    A/G
rs1235209161 chr20:58818299    C/T
rs1331296704 chr20:58818298    T/C
rs755174560 chr20:58818297    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-298
Exosome Serum     18589210
Exosome K562 cells     24460325
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-298
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRanda
Support Database ViRBase

References:


[1]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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