Detail Information

Basic Information:


  VIRBase ID:  

HVID00009523

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-362-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0004683 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-362-3p
rs1161783537 chrX:50009014    A/G
rs1420083671 chrX:50009019    A/G
rs1557182053 chrX:50009016    T/G
rs1557182056 chrX:50009025    C/T
rs1048552733 chrX:50009006    A/G
rs1557182050 chrX:50009012    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-362-3p
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-362-3p
Tetrangulol 99188 Drug sensitive
Midostaurin 9829523 Drug resistant
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant
Pentamidine isethionate 8813 Drug sensitive
Acridine Yellow G 8672 Drug resistant
Benzethonium chloride 8478 Drug sensitive
2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive
Fascaplysine 73292 Drug sensitive
5-Methyl-1,10-phenanthroline 72791 Drug resistant
Berberine iodide 72350 Drug sensitive
Coptisine chloride 72321 Drug sensitive
7-Hydroxystaurosporine 72271 Drug resistant
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug sensitive
Lauryl isoquinolinium bromide 7132 Drug sensitive
Anaxirone 71218 Drug resistant
Thiocoraline 70698112 Drug resistant
Resorufin 69462 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Laurolinium acetate 67354 Drug sensitive
Tacacoside A2 6712615 Drug sensitive
Baccharinoid B4 6711263 Drug sensitive
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug resistant
Mevastatin 64715 Drug resistant
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
Bleomycin 5460769 Drug resistant
Berberal 5351462 Drug sensitive
Proscillaridin 5284613 Drug resistant
Ayanin 5280682 Drug resistant
Purapuridine 5250 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug resistant
Latrunculin a 445420 Drug resistant
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Antibiotic X-14766A 434840 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Mitoxantrone 4212 Drug resistant
Menadione 4055 Drug sensitive
Homocoralyne sulfopropionate 40154 Drug sensitive
Bortezomib 387447 Drug sensitive
19-Hydroxy-8-O-methyltetrangulol 379539 Drug sensitive
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant
Girolline 362388 Drug resistant
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
Acronycine, 2-nitro 342903 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
Dasatinib 3062316 Drug resistant
N-[1-(Biphenyl-4-yl)ethyl]-3,4-dichlorobenzamide 305114 Drug resistant
Deoxycamptothecin 266552 Drug resistant
Gardenin A 261859 Drug resistant
3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug resistant
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
Cytembena 23665583 Drug sensitive
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug resistant
Kinetin riboside 20345 Drug resistant
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Solvent red 1 14678 Drug resistant
Amphethinile 146332 Drug sensitive
[(1R,5R)-16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate 146159135 Drug resistant
(2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive
1,3-Diamino-5-methylphenazinium chloride 14132 Drug sensitive
Dtxsid30327893 138402823 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 3,4-dihydro-3-beta-D-ribofuranosyl-(9CI) 135492361 Drug resistant
Formycin b 135449281 Drug resistant
Pyrazofurin 135413551 Drug resistant
4-[2-[4-(2-Methylprop-1-enyl)-2-oxoindol-3-yl]hydrazinyl]benzenesulfonamide 135409809 Drug resistant
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant
15-Deacetylsergeolide 125729 Drug sensitive
10-Desacetylbaccatin III 125001 Drug sensitive
Berberine chloride 12456 Drug sensitive
Pepleo 122804 Drug resistant
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant
(5S,7S)-5,7,9,10-Tetrahydroxy-2-methoxy-7-methyl-6,8-dihydro-5H-anthracene-1,4-dione 11209399 Drug sensitive
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant
Unii-9JU14BJ5QG 109374088 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Chimaphilin 101211 Drug sensitive
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug resistant
4-methoxy-2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine - Drug resistant
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug resistant
6-aryl alkyl fluoro quinolone derivative - Drug resistant
7-pentanoyltaxol - Drug resistant
Annamycin Liposomal - Drug resistant
antineoplastic-d655481 - Drug resistant
euchrysine - Drug resistant
geldanamycin dimethylglycinate - Drug resistant
Indenoisoquinoline derivative - Drug resistant
organosulfur compound - Drug resistant
stereoisomer of nsc 675784-h - Drug resistant
tgf.alpha.-pe40 - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
tp4ek-k6 - Drug resistant
tunicamycin - Drug resistant
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
2-chloro-3-amino-5,8-dihydoxy-1,4-naphthoquinone - Drug sensitive
arabinofuranosyl cytosine 5'-oleyl phosphate monosodium, - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug sensitive
naphtho[1,2-b]quinolizinium, 10,13-dimethyl- chloride - Drug sensitive
naphtho[1,2-c]quinolizinium, 13-methyl-, chloride - Drug sensitive
naphtho[2,1-b]quinolizinium, 7-methyl- chloride - Drug sensitive
naphtho[2,3-b]furan-4,9-dione, 2-bromo- - Drug sensitive
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate - Drug sensitive
thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
5-hydroxyamino camptothecin - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
b705009k098 - Drug sensitive
chalmydocin - Drug sensitive
chlorambucil-spermidine - Drug sensitive
discorhabdin i - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-362-3p
D-Glucose 5793 Drug interaction    RC00007070
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-362-3p
Cisplatin 5702198       21575166

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-362-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRanda
Support Database ViRBase

References:


[1]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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