Detail Information

Basic Information:


  VIRBase ID:  

HVID00009520

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-296-3p ORF3a
miRBase
Accession/Entrez ID		 MIMAT0004679 43740569
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp03

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-296-3p
rs1036021775 chr20:58817629    G/A
rs117258475 chr20:58817631    G/A
rs1352715245 chr20:58817638    C/T
rs376743676 chr20:58817632    C/T
rs767068961 chr20:58817647    C/G
rs772229115 chr20:58817637    AC/A
rs1357635912 chr20:58817643    C/T
rs533608618 chr20:58817642    A/T
rs777856691 chr20:58817640    CA/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-296-3p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome HCC tissues     30542726
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-296-3p
D-Glucose 5793 Drug interaction    RC00007064
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-296-3p
Cisplatin 5702198       25356050
Cisplatin 5702198       27186308
Temozolomide 5394       22999387
Imatinib 5291       22999387
Etoposide 36462       22999387
Paclitaxel 36314       27186308
5-Fluorouracil 3385       27186308
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-296-3p
Interactor2: ORF3a

Evidence Support:


Prediction-Evidence miRanda//miRTarP
Support Database ViRBase

References:


[1]PMID 33801496 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Additionally, if targets are selected by both tools in at least two strains of SARS-CoV-2, we only considered them as potential targets of miRNA on SARS-CoV-2 (Table S2). In Table 1, we present the list of miRNAs meeting all these criteria.
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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