Detail

Detail Information

Basic Information:

VIRBase ID:

HVID00009433

Virus:

SARS-CoV-2 (NC_045512.2)

Host:

Homo sapiens

Confidence Score:

0.1828

Interaction Type:

Host-Virus interaction

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-411-5p	ORF10
miRBase Accession/Entrez ID	MIMAT0003329	43740576
Organism	Homo sapiens	SARS-CoV-2 (NC_045512.2)
Category	miRNA	mRNA
Alias	-	GU280_gp11

ncRNA SNP information:

Resource

Symbol

SNP ID

SNP Position

Ref/Alt

miRNASNP-v3

hsa-miR-411-5p

rs1361369657	chr14:101023352	T/TA
rs536735599	chr14:101023348	C/T
rs567582018	chr14:101023340	T/C
rs751955845	chr14:101023355	C/T
rs757784113	chr14:101023356	G/A
rs758726179	chr14:101023349	G/A
rs764544909	chr14:101023354	G/A
rs780559779	chr14:101023359	C/T
rs1157612570	chr14:101023345	G/C
rs1165649618	chr14:101023341	A/G
rs753033941	chr14:101023343	T/C

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

hsa-miR-411-5p

Exosome	Serum	18589210
Exosome	Plasma	23663360
Exosome	B cell lymphoma cell lines\|EBV-transformed lymphoblastoid B cells	25242326
Exosome	Blood\|B lymphoblastoid cells\|Endothelial cells\|Mast cells	-
Microvesicle	Follicular fluid	23666971
Microvesicle	Blood\|Fibroblasts\|Mesenchymal stem cells\|Urine	-
Mitochondrion	Skeletal muscle myoblasts	21637849

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-411-5p

Interactor2: ORF10

Evidence Support:

Prediction-Evidence	miRBase
Support Database	ViRBase

References:

PMID	32547891	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Among 2,654 mature entries ofÂ Homo sapiensÂ in miRBase Release 22.1, 479 of them could target SARS-CoV-2 genes (Supplemental Files-human to virus). While Envelope and ORF6 genes were targeted by single miRNAs, ORF1ab appeared to be the target of 369 different human mature miRNAs (Table 2).

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