Detail Information

Basic Information:


  VIRBase ID:  

HVID00009380

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-539-5p N
miRBase
Accession/Entrez ID		 MIMAT0003163 43740575
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-539-5p
rs1261686093 chr14:101047338    A/G
rs1397145918 chr14:101047350    TTCGCTTTATTTA/T
rs747290147 chr14:101047347    G/A
rs750261997 chr14:101047326    TGAG/T
rs920592001 chr14:101047329    G/A
rs1037241141 chr14:101047332    G/T
rs949143380 chr14:101047330    G/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-539-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-539-5p
8-Aminoadenosine 96851 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Berberine iodide 72350 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
2-Azaadenine 5480214 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Isobrucein A 441802 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Antimycin A3 245869 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
Kinetin riboside 20345 Drug resistant
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug resistant
(1S,3S,5'R,6S,6'S,8R,9Z,14R,15S,16R,17R,18R,19S,20S,21E,25S,27S,29R)-3,14,15,17,19,20-Hexahydroxy-6'-[(2S)-2-hydroxybutyl]-16-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',6,14,18,20,29-hexamethylspiro[4,24,28-trioxatricyclo[23.3.1.03,8]nonacosa-9,21-diene-27,2'-oxane]-23-one 139589095 Drug sensitive
Formycin b 135449281 Drug resistant
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
2-bromo-3-ketocastanospermine - Drug resistant
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
leucinostatine d - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-539-5p
Atorvastatin 60823 Drug interaction    RC00005841
Doxorubicin 31703 Drug interaction    RC00005840
Verapamil 2520 Drug interaction    RC00005839
Biotin 171548 Drug interaction    RC00005842

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-539-5p
Interactor2: N

Evidence Support:


Prediction-Evidence miRanda
Support Database ViRBase

References:


[1]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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