Detail Information

Basic Information:


  VIRBase ID:  

HVID00009378

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-455-5p ORF8
miRBase
Accession/Entrez ID		 MIMAT0003150 43740577
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp09

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-455-5p
rs1288139869 chr9:114209467    A/G
rs1414847416 chr9:114209466    C/T
rs552585852 chr9:114209470    G/A
rs552585852 chr9:114209470    G/T
rs776650840 chr9:114209469    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-455-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-455-5p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
CID 9604911 9604911 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive
Chalcone analog 6296717 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Latrunculin a 445420 Drug sensitive
Trichopolyn 431962 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
Thiosangivamycin 3580213 Drug resistant
Dasatinib 3062316 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug resistant
Antineoplastic-633273 15954131 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
Berberine chloride 12456 Drug resistant
p-Toluquinone 11122 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
leucinostatine d - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
(-)-furodysinin - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-455-5p
Gemcitabine 60750 Drug interaction    RC00005824
Vincristine 5978 Drug interaction    RC00005821
Prednisone 5865 Drug interaction    RC00005820
Temozolomide 5394 Drug interaction    RC00005819
Etoposide 36462 Drug interaction    RC00005823
5-Fluorouracil 3385 Drug interaction    RC00005818
Doxorubicin 31703 Drug interaction    RC00005822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817
Verapamil 2520 Drug interaction    RC00005816
Docetaxel 148124 Drug interaction    RC00005826
Methotrexate 126941 Drug interaction    RC00005825
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-455-5p
Cisplatin 5702198       21575166
5-Fluorouracil 3385       25356050
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-455-5p
Panobinostat       6918837
Irinotecan       60838
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-455-5p
Interactor2: ORF8

Evidence Support:


Prediction-Evidence miRBase
Support Database ViRBase

References:


PMID 32547891 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among 2,654 mature entries of Homo sapiens in miRBase Release 22.1, 479 of them could target SARS-CoV-2 genes (Supplemental Files-human to virus). While Envelope and ORF6 genes were targeted by single miRNAs, ORF1ab appeared to be the target of 369 different human mature miRNAs (Table 2).

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