Detail Information

Basic Information:


  VIRBase ID:  

HVID00009371

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-506-3p N
miRBase
Accession/Entrez ID		 MIMAT0002878 43740575
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-506-3p
rs1440077796 chrX:147230755    T/A
rs1557101375 chrX:147230755    T/TACTC
rs1557101378 chrX:147230756    A/G
rs781957222 chrX:147230757    C/T
rs782106326 chrX:147230763    A/C
rs782157338 chrX:147230773    A/C
rs782157338 chrX:147230773    A/G
rs1401391281 chrX:147230770    CTTACAAATA/C
rs782769778 chrX:147230766    G/A
rs782769778 chrX:147230766    G/T
rs895911514 chrX:147230769    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-506-3p
Exosome Brain tissue     23382797
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-506-3p
Tetrangulol 99188 Drug sensitive
Midostaurin 9829523 Drug resistant
Actinomycin X4357G methoxime 9573583 Drug sensitive
1-(4-Methoxyphenyl)-3-[(2-oxo-3-indolyl)amino]thiourea 947057 Drug resistant
Tiotixene 941651 Drug sensitive
Cyclo[N-methyl-L-alanyl-beta-alanyl-(2R)-2-hydroxy-4-pentenoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl] 91746256 Drug sensitive
Acridine Yellow G 8672 Drug resistant
2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive
Clothixamide maleate 76972759 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Secalonic acid D 73431 Drug sensitive
Coptisine chloride 72321 Drug sensitive
Resorufin 69462 Drug sensitive
Sulbentine 67686 Drug sensitive
3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug sensitive
Tacacoside A2 6712615 Drug sensitive
Rufigallol 65737 Drug resistant
Verrucarin A 6326658 Drug sensitive
Primaquine phosphate 6135 Drug sensitive
Methylene blue 6099 Drug sensitive
Tributyrin 6050 Drug sensitive
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-(1H-pyrrol-2-yl)thieno[3,2-d]pyrimidin-4-amine;hydrochloride 57401575 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant
Caracemide 54747 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
Tetrocarcin A, sodium salt 54724658 Drug sensitive
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive
Di-p-tolyliodinium bromide 54601177 Drug sensitive
Herveline O 5459269 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug sensitive
Thiram 5455 Drug sensitive
Xestin A 5352066 Drug resistant
Dihydro-5-azacytidine 5351280 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug sensitive
5-[2-(4-Hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxamide 53239975 Drug sensitive
Vorinostat 5311 Drug sensitive
5-Fluoro-2'-deoxycytidine 515328 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug resistant
3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug resistant
Mitoxantrone 4212 Drug resistant
Cyano pyridine-P-CH3 406496 Drug sensitive
S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug sensitive
Purpureagitosid 401298 Drug resistant
Triacetyl crambescidin 800 hydrochloride 400721 Drug sensitive
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive
Trapoxin B 395803 Drug sensitive
Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)seleno]- 3879067 Drug sensitive
Bortezomib 387447 Drug sensitive
3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant
2-Ethenyl estradiol 381026 Drug sensitive
19-Hydroxy-8-O-methyltetrangulol 379539 Drug sensitive
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug sensitive
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug sensitive
5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
Diethyl p-phenoxybenzalmalonate 370253 Drug sensitive
1,2-Dimethyl-phenothiazone 369387 Drug sensitive
3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive
Girolline 362388 Drug resistant
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive
7alpha-Acetoxyroylenane 362048 Drug sensitive
Antineoplastic-615804 355949 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
Acronycine, 2-nitro 342903 Drug sensitive
Pyrazoloacridine 339455 Drug resistant
Helenin 327378 Drug sensitive
Ellipticine 3213 Drug resistant
Valproic acid 3121 Drug sensitive
9-Methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 3086380 Drug resistant
Dasatinib 3062316 Drug resistant
Clomifene citrate 3033832 Drug sensitive
Phenanthrene-9,10-diimine 2981 Drug sensitive
Antineoplastic-92915 261051 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
CID 24197685 24197685 Drug sensitive
Mepacrine mustard dihydrochloride 24180972 Drug resistant
Cytembena 23665583 Drug sensitive
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug resistant
Kinetin riboside 20345 Drug resistant
Actinomycin VII 20055431 Drug sensitive
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug sensitive
Chonemorphine 165208 Drug sensitive
Ellipticine analog 148569 Drug resistant
Diphenyltin dichloride 14342 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
Discorhabdin B 135409044 Drug sensitive
8-Azaguanine 135403646 Drug sensitive
(1S,2S,11R,15S,18S)-9,10,15,18-Tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one 134694721 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant
15-Deacetylsergeolide 125729 Drug sensitive
Berberine chloride 12456 Drug sensitive
Pepleo 122804 Drug resistant
Melampodinin 11953936 Drug sensitive
Clofarabine 119182 Drug resistant
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
(5S,7S)-5,7,9,10-Tetrahydroxy-2-methoxy-7-methyl-6,8-dihydro-5H-anthracene-1,4-dione 11209399 Drug sensitive
Acetylenedicarboxamide 10971 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug resistant
Bialamicol 10304 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
Withajardin C 102469053 Drug sensitive
Cepharanthine 10206 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Selumetinib 10127622 Drug sensitive
Chimaphilin 101211 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug resistant
4-methoxy-2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
6-aryl alkyl fluoro quinolone derivative - Drug resistant
Anthrapyrazole derivative - Drug resistant
antineoplastic-d655481 - Drug resistant
Camptothecin Derivative - Drug resistant
geldanamycin dimethylglycinate - Drug resistant
il4(38-37)-pe38kdel - Drug resistant
Indenoisoquinoline derivative - Drug resistant
strophanthin - Drug resistant
tgf.alpha.-pe40 - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
tp4ek-k6 - Drug resistant
tunicamycin - Drug resistant
viridomycin - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4(1h)-quinazolinone, 2,3-dihydro-2-(1-naphthyl)- (8ci) - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug sensitive
6-(4-hydroxy-2-methylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
isoindolo[1,2-b]quinazoline, 10,12-dihydro-3-methyl-12-oxo- - Drug sensitive
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug sensitive
naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug sensitive
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate - Drug sensitive
thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
5-hydroxyamino camptothecin - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-d183258 - Drug sensitive
chlorambucil-spermidine - Drug sensitive
crambescidin 800 trihydrochloride - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
geldanamycin deriv - Drug sensitive
hymenialdisine - Drug sensitive
methyl 3-farnesylthioacetate - Drug sensitive
protein toxin c 10 - mw approx. 6700 - Drug sensitive
rh(iii)-amodiaquine - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
xenorhabdin 1 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-506-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00005748
D-Glucose 5793 Drug interaction    RC00005747
Estradiol 5757 Drug interaction    RC00005746
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005745
Olaparib 23725625 Drug interaction    RC00005749
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-506-3p
Gefitinib 123631       30535506

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-506-3p
Interactor2: N

Evidence Support:


Prediction-Evidence IntaRNA//miRanda//psRNATarget
Support Database ViRBase

References:


PMID 32765592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description From our rigorous analysis pipeline, which covers three different well-established algorithms (IntaRNA, miRanda, and psRNATarget) to predict RNA-RNA interactions, we have identified 122 and 106 host antiviral miRNAs against SARS-CoV (R) and SARS-CoV-2 (R), respectively (Figures 2A,B, Supplementary File 2).

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