Detail Information

Basic Information:


  VIRBase ID:  

HVID00009279

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-154-5p N
miRBase
Accession/Entrez ID		 MIMAT0000452 43740575
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-154-5p
rs1339080441 chr14:101059785    C/T
rs375213313 chr14:101059778    C/G
rs375213313 chr14:101059778    C/T
rs41286570 chr14:101059790    G/A
rs41286570 chr14:101059790    G/C
rs575922548 chr14:101059779    G/A
rs770620613 chr14:101059789    C/T
rs772665345 chr14:101059769    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-154-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-154-5p
8-Aminoadenosine 96851 Drug resistant
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant
Berberine iodide 72350 Drug sensitive
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Silver mesylate 6712944 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant
Crotonoside 65085 Drug resistant
3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive
2-Azaadenine 5480214 Drug resistant
Antibiotic 1907-VIII 5477807 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
[(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant
Varacin trifluoroacetate salt 54611558 Drug resistant
2-Methylolivacinium acetate 5458752 Drug sensitive
Xestin A 5352066 Drug resistant
Berberal 5351462 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Vorinostat 5311 Drug resistant
6-Bromosangivamycin 470030 Drug resistant
Justicidin B 442882 Drug resistant
Suavedol 442245 Drug resistant
Musennin 441933 Drug sensitive
Isobrucein A 441802 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
2-Hydroxy discorhabdin D 362391 Drug resistant
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Haloprogin 3561 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Ellipticine 3213 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
Sarcoviolin 24202820 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
Kinetin riboside 20345 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Paucin 161538 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
(1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Acid Alizarine Red B 135565636 Drug sensitive
Oxanthrazole 135502299 Drug sensitive
Formycin b 135449281 Drug resistant
Salicylidene salicylhydrazide 135445765 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
Berberine chloride 12456 Drug sensitive
Litmomycin 12310334 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant
2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive
1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
granatomycin a - Drug resistant
o-linoleoyl-2-butoxy-1-desoamine - Drug resistant
naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-methylellpticinium - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-154-5p
Gemcitabine 60750 Drug interaction    RC00003199
Doxorubicin 31703 Drug interaction    RC00003198
Verapamil 2520 Drug interaction    RC00003197
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003200

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-154-5p
Interactor2: N

Evidence Support:


Prediction-Evidence miRBase
Support Database ViRBase

References:


PMID 32547891 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among 2,654 mature entries of Homo sapiens in miRBase Release 22.1, 479 of them could target SARS-CoV-2 genes (Supplemental Files-human to virus). While Envelope and ORF6 genes were targeted by single miRNAs, ORF1ab appeared to be the target of 369 different human mature miRNAs (Table 2).

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