Detail Information

Basic Information:


  VIRBase ID:  

HVID00009265

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-138-5p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0000430 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-138-5p
rs1159226412 chr3:44114256    G/A
rs1331169318 chr3:44114250    C/A
rs1331169318 chr3:44114250    C/T
rs1466470291 chr3:44114249    T/A
rs748499444 chr3:44114243    T/C
rs1285034653 chr16:56858546    G/A
rs1389589086 chr16:56858539    G/A
rs1395610282 chr16:56858535    T/C
rs749468995 chr16:56858548    C/G
rs755213420 chr16:56858549    G/A
rs755213420 chr16:56858549    G/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-138-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|Endothelial cells     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-138-5p
Fludarabine 657237 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 22 6539364 Drug resistant
Psammaplin A 6400741 Drug sensitive
Melampodin B acetate 5359212 Drug resistant
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug resistant
Reumycin 5351216 Drug sensitive
Streptonigrin 5298 Drug sensitive
Ayanin 5280682 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Formycin A 447199 Drug sensitive
Triacetyl crambescidin 800 hydrochloride 400721 Drug resistant
Massoia lactone 39914 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant
Antineoplastic-642316 369949 Drug resistant
6-(Dimethylarsanylsulfanylmethyl)oxane-2,3,4,5-tetrol 311912 Drug resistant
N-[1-(Biphenyl-4-yl)ethyl]-3,4-dichlorobenzamide 305114 Drug sensitive
2,4,6-Trichloro-5-ethylpyrimidine 249455 Drug resistant
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive
2,4-Dihydroxybenzaldehyde 2-pyridylhydrazone 135509512 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Litmomycin 12310334 Drug resistant
Binimetinib 10288191 Drug resistant
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug resistant
12h-benzoxazolo[2,3-b]quinazolin-12-one, 3-nitro- - Drug resistant
2,4-pentanedionato(1,5-cyclooctadiene)rhodium - Drug resistant
21h,23h-porphine, pyridinium deriv., silver complex - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
2-(1-(4-chlorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant
9-methoxy-5-hydroxycamptothecin - Drug resistant
antineoplastic-625543 - Drug resistant
b705009k098 - Drug resistant
bis(2-nitrophenyl)sulfilimine - Drug resistant
ERB-38 Immunotoxin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 10-methoxy- - Drug sensitive
breast chalone, glycoprotein fraction - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
(-)-furodysinin - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
crotoxin cd - Drug sensitive
insulin-methotrexate conjugate - Drug sensitive
protein toxin c 10 - mw approx. 6700 - Drug sensitive
staurosporin analog kt 5944 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-138-5p
Gemcitabine 60750 Drug interaction    RC00002766
Vincristine 5978 Drug interaction    RC00002763
D-Glucose 5793 Drug interaction    RC00002762
Diethylstilbestrol 448537 Drug interaction    RC00002771
Cyclopamine 442972 Drug interaction    RC00002770
Paclitaxel 36314 Drug interaction    RC00002765
5-Fluorouracil 3385 Drug interaction    RC00002761
Doxorubicin 31703 Drug interaction    RC00002764
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002760
Docetaxel 148124 Drug interaction    RC00002769
Gefitinib 123631 Drug interaction    RC00002768
Ginsenoside Rh2 119307 Drug interaction    RC00002767
Y15 - Drug interaction    RC00002773
FAK inhibitor - Drug interaction    RC00002772
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-138-5p
Cisplatin 5702198       30535472
Gefitinib 123631       24582749

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-138-5p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence IntaRNA//miRanda//psRNATarget
Support Database ViRBase

References:


[1]PMID 32765592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description From our rigorous analysis pipeline, which covers three different well-established algorithms (IntaRNA, miRanda, and psRNATarget) to predict RNA-RNA interactions, we have identified 122 and 106 host antiviral miRNAs against SARS-CoV (R) and SARS-CoV-2 (R), respectively (Figures 2A,B, Supplementary File 2).
[2]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[3]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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