Detail Information

Basic Information:


  VIRBase ID:  

HVID00008722

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-375-5p ORF3a
miRBase
Accession/Entrez ID		 MIMAT0037313 1489669
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sars3a

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-375-5p
rs1207124480 chr2:219001696    G/C
rs1285474297 chr2:219001691    G/A
rs1484983849 chr2:219001693    G/A
rs990524627 chr2:219001704    C/T
rs1262819504 chr2:219001700    G/A
rs996281351 chr2:219001702    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-375-5p
Exosome Serum     18589210
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Cerebrospinal fluid     25420022
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Mitochondrion Cell line (HEK-293)     22984580

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-375-5p
Interactor2: ORF3a

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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