Detail Information

Basic Information:


  VIRBase ID:  

HVID00007926

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-550b-2-5p M
miRBase
Accession/Entrez ID		 MIMAT0022737 1489672
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sars5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-550b-2-5p
rs771040958 chr7:30289864    C/CGG
rs1317042321 chr7:30289866    T/G
rs752029293 chr7:30289865    C/A
rs752029293 chr7:30289865    C/T
rs753579908 chr7:30289854    T/C
rs753579908 chr7:30289854    T/G
rs754718902 chr7:30289863    C/T
rs757638598 chr7:30289867    C/A
rs758569467 chr7:30289864    C/T
rs1397804079 chr7:32733052    C/T
rs1480179700 chr7:32733041    T/G
rs753385000 chr7:32733050    C/A
rs753385000 chr7:32733050    C/T
rs754544327 chr7:32733054    C/A
rs754544327 chr7:32733054    C/T
rs377130215 chr7:30289872    A/G
rs1328607345 chr7:32733060    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-550b-2-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-550b-2-5p
Interactor2: M

Evidence Support:


Prediction-Evidence IntaRNA//miRanda//miRTarP//psRNATarget
Support Database ViRBase

References:


[1]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).
[2]PMID 32765592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description From our rigorous analysis pipeline, which covers three different well-established algorithms (IntaRNA, miRanda, and psRNATarget) to predict RNA-RNA interactions, we have identified 122 and 106 host antiviral miRNAs against SARS-CoV (R) and SARS-CoV-2 (R), respectively (Figures 2A,B, Supplementary File 2).

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