Detail Information

Basic Information:


  VIRBase ID:  

HVID00007736

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4763-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0019913 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4763-3p
rs111509618 chr22:46113644    C/CG
rs1293184635 chr22:46113643    G/A
rs1293184635 chr22:46113643    G/T
rs1480117916 chr22:46113632    G/T
rs574975013 chr22:46113636    G/A
rs748191060 chr22:46113644    C/G
rs748191060 chr22:46113644    C/T
rs768794912 chr22:46113637    T/G
rs781389774 chr22:46113639    C/T
rs909576682 chr22:46113642    G/A
rs927719598 chr22:46113645    G/A
rs927719598 chr22:46113645    G/C
rs927719598 chr22:46113645    G/T
rs1193544941 chr22:46113631    G/A
rs1216027531 chr22:46113627    C/T
rs1339640536 chr22:46113626    G/C
rs1483337396 chr22:46113624    AGGCAGG/A
rs967155183 chr22:46113630    G/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4763-3p
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-4763-3p
Vincristine 5978 Drug interaction    RC00008583
5-Fluorouracil 3385 Drug interaction    RC00008582
Doxorubicin 31703 Drug interaction    RC00008584
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008581
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-4763-3p
5-Fluorouracil 3385       23525256

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4763-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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