Detail Information

Basic Information:


  VIRBase ID:  

HVID00007322

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-378d ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0018926 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-378d
rs1215256756 chr4:5923287    T/C
rs1032722477 chr4:5923292    G/A
rs1302915342 chr4:5923293    T/G
rs1344067493 chr4:5923295    C/T
rs376196852 chr8:93916091    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-378d
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-378d
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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