Detail Information

Basic Information:


  VIRBase ID:  

HVID00006908

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1299 ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0005887 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1299
rs1009712608 chr9:40929012    C/T
rs747216379 chr9:40929013    C/G
rs747216379 chr9:40929013    C/T
rs753922180 chr9:40928993    GAGGGTCTGAATGTTTGTCCC/G
rs796108267 chr9:40929011    C/T
rs796728500 chr9:40929010    T/C
rs1042551075 chr9:40929028    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1299
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1299
Gemcitabine 60750 Drug interaction    RC00007746
Eloxatine 5310940 Drug interaction    RC00007748
Doxorubicin 31703 Drug interaction    RC00007745
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007744
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1299
Topotecan       60700
l-685,458       5479543
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1299
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

Starting a new search, please wait ...