Detail Information

Basic Information:


  VIRBase ID:  

HVID00006847

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1226-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0005577 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1226-3p
rs141645399 chr3:47849627    T/C
rs1431438028 chr3:47849618    T/C
rs1472927902 chr3:47849608    T/C
rs372320878 chr3:47849626    C/T
rs373981655 chr3:47849616    C/T
rs747968275 chr3:47849619    G/A
rs370902478 chr3:47849609    C/T
rs750372577 chr3:47849612    C/A
rs754955605 chr3:47849613    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1226-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1226-3p
Gemcitabine 60750 Drug interaction    RC00007606
5-Fluorouracil 3385 Drug interaction    RC00007604
Doxorubicin 31703 Drug interaction    RC00007605
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-1226-3p
5-Fluorouracil 3385       25356050
Doxorubicin 31703       25698578

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1226-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

Starting a new search, please wait ...