Detail Information

Basic Information:


  VIRBase ID:  

HVID00006778

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-298 ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0004901 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-298
rs201036298 chr20:58818294    T/G
rs550848896 chr20:58818288    C/A
rs550848896 chr20:58818288    C/T
rs751823623 chr20:58818295    G/T
rs910750200 chr20:58818287    A/G
rs1235209161 chr20:58818299    C/T
rs1331296704 chr20:58818298    T/C
rs755174560 chr20:58818297    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-298
Exosome Serum     18589210
Exosome K562 cells     24460325
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-298
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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