Detail Information

Basic Information:


  VIRBase ID:  

HVID00006763

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-550a-5p M
miRBase
Accession/Entrez ID		 MIMAT0004800 1489672
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sars5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-550a-5p
rs1424923463 chr7:30289834    G/A
rs1461900988 chr7:30289836    C/A
rs373052300 chr7:30289837    CTGT/C
rs767410044 chr7:30289835    C/T
rs768467829 chr7:30289824    G/A
rs768467829 chr7:30289824    G/T
rs113464681 chr7:32733024    CTGT/C
rs1229778253 chr7:32733020    AG/A
rs767458159 chr7:32733023    C/A
rs767458159 chr7:32733023    C/T
rs763112889 chr7:30289821    T/C
rs763112889 chr7:30289821    T/G
rs775702625 chr7:30289816    G/A
rs1279287578 chr7:32733013    G/T
rs1332837861 chr7:32733007    C/A
rs1449268212 chr7:32733009    G/C
rs1469349047 chr7:32733006    C/T
rs758925827 chr7:32733008    TGAGGGAGTAA/T
rs761675265 chr7:32733003    G/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-550a-5p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-550a-5p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
Gardenin B 96539 Drug sensitive
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
Sulbentine 67686 Drug sensitive
2-Debenzoyl-2-(3',5'-difluorobenzoyl)-A-nortaxol 6712230 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Artelasticin 5471311 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Bromo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329234 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Spiperone 5265 Drug resistant
Lychnopholide 49767028 Drug sensitive
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive
11-Hydroxyusambarine Chlorhydrate 401426 Drug sensitive
Artelastin 399488 Drug sensitive
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive
Sjg-136 393111 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
5-(4-Azido-3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine 353605 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
Predorine 333830 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
3-[(1R)-1-(2-Chlorophenyl)ethoxy]-5-{6-[(2S)-2,3-dihydroxypropoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide 25263120 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
Prumycin HCl 24197905 Drug resistant
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Kinetin riboside 20345 Drug resistant
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
Emofolin sodium 135475347 Drug sensitive
6-Aryl-pyrazolo[3,4-b]pyridine analogue 23 135435015 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Melampodinin 11953936 Drug sensitive
(3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
(Z)-N-phenyl-3-(3,4,5-trimethoxystyryl)pyridin-2-amine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive
bersaldegenin 1,3,5-orthoacetate - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
aromoline - Drug sensitive
euchrysine - Drug sensitive
his 47-methyl ct - Drug sensitive
isatin dr - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-550a-5p
Atorvastatin 60823 Drug interaction    RC00007201
Eloxatine 5310940 Drug interaction    RC00007203
5-Fluorouracil 3385 Drug interaction    RC00007199
Doxorubicin 31703 Drug interaction    RC00007200
Tamoxifen 2733526 Drug interaction    RC00007202
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-550a-5p
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-550a-5p
Interactor2: M

Evidence Support:


Prediction-Evidence IntaRNA//miRanda//miRTarP//psRNATarget
Support Database ViRBase

References:


[1]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).
[2]PMID 32765592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description From our rigorous analysis pipeline, which covers three different well-established algorithms (IntaRNA, miRanda, and psRNATarget) to predict RNA-RNA interactions, we have identified 122 and 106 host antiviral miRNAs against SARS-CoV (R) and SARS-CoV-2 (R), respectively (Figures 2A,B, Supplementary File 2).

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