Detail Information

Basic Information:


  VIRBase ID:  

HVID00006752

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-500a-5p N
miRBase
Accession/Entrez ID		 MIMAT0004773 1489678
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sars9a

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-500a-5p
rs1221490724 chrX:50008465    A/G
rs1557181893 chrX:50008443    T/G
rs1557181895 chrX:50008452    C/G
rs1557181897 chrX:50008453    T/A
rs1557181900 chrX:50008458    G/A
rs1557181900 chrX:50008458    G/C
rs1557181904 chrX:50008463    A/T
rs369176381 chrX:50008450    T/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-500a-5p
Exosome Primary dendritic cells     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-500a-5p
Interactor2: N

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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