Detail Information

Basic Information:


  VIRBase ID:  

HVID00006691

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-150-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0004610 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-150-3p
rs1222701309 chr19:49500798    T/C
rs1268655804 chr19:49500801    C/T
rs1479556921 chr19:49500803    C/A
rs900688289 chr19:49500802    C/T
rs1184577625 chr19:49500811    T/C
rs1270941119 chr19:49500816    C/T
rs1413039185 chr19:49500817    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-150-3p
Exosome Saliva     19627513
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-150-3p
Ginsenoside Rh2 119307 Drug interaction    RC00006970
Androstanolone 10635 Drug interaction    RC00006969
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-150-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-150-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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