Detail Information

Basic Information:


  VIRBase ID:  

HVID00006514

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-589-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0003256 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-589-3p
rs1049301106 chr7:5495848    T/C
rs1276512832 chr7:5495846    C/T
rs1324236236 chr7:5495841    A/G
rs1325949855 chr7:5495842    C/G
rs372099307 chr7:5495838    G/A
rs375178432 chr7:5495844    G/A
rs375178432 chr7:5495844    G/C
rs560730191 chr7:5495840    A/G
rs752134836 chr7:5495843    C/T
rs911558892 chr7:5495839    G/A
rs1233118791 chr7:5495854    C/T
rs1319027993 chr7:5495851    G/A
rs1319027993 chr7:5495851    G/T
rs751258950 chr7:5495856    G/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-589-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-589-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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