Detail Information

Basic Information:


  VIRBase ID:  

HVID00006511

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-588 S
miRBase
Accession/Entrez ID		 MIMAT0003255 1489668
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - E2//sars2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-588
rs1221870465 chr6:126484654    A/G
rs1305299278 chr6:126484655    A/G
rs1439105717 chr6:126484666    C/A
rs761187038 chr6:126484656    TG/T
rs765028368 chr6:126484663    G/T
rs903390621 chr6:126484659    G/A
rs1041858987 chr6:126484651    C/T
rs1444441984 chr6:126484649    G/T
rs761948782 chr6:126484653    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-588
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-588
Doxorubicin 31703 Drug interaction    RC00006055
Verapamil 2520 Drug interaction    RC00006054
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-588
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-588
Interactor2: S

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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