Detail Information

Basic Information:


  VIRBase ID:  

HVID00006416

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-512-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0002823 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-512-3p
rs1199485634 chr19:53666744    T/C
rs1196396604 chr19:53669224    T/C
rs1316686892 chr19:53669223    A/G
rs1316686892 chr19:53669223    A/T
rs1444535542 chr19:53669228    T/C
rs567404589 chr19:53669229    G/A
rs759933661 chr19:53669227    C/T
rs765914747 chr19:53669232    G/A
rs746404558 chr19:53666736    G/A
rs757627265 chr19:53666731    G/A
rs757627265 chr19:53666731    G/C
rs781608931 chr19:53666733    G/T
rs754282354 chr19:53669220    G/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-512-3p
Exosome Brain tissue     23382797
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-512-3p
D-Glucose 5793 Drug interaction    RC00005511
Trichostatin A 444732 Drug interaction    RC00005512
Emodin 3220 Drug interaction    RC00005510
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005509
Tamoxifen 2733526 Drug interaction    RC00005513
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00005514
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-512-3p
Cisplatin 5702198       21575166
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-512-3p
Topotecan       60700
Paclitaxel       36314
Crizotinib       11626560
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-512-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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