Detail Information

Basic Information:


  VIRBase ID:  

HVID00006387

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-431-5p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0001625 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-431-5p
rs1174427606 chr14:100881041    C/T
rs1309976089 chr14:100881036    G/C
rs1478302726 chr14:100881040    T/C
rs199509151 chr14:100881038    C/T
rs749060583 chr14:100881039    G/A
rs768621020 chr14:100881044    G/A
rs774140527 chr14:100881046    A/G
rs1238626395 chr14:100881032    G/A
rs1458881469 chr14:100881033    C/T
rs940385288 chr14:100881029    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-431-5p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Endothelial cells     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-431-5p
Dichloroallyl lawsone 277767 Drug sensitive
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-431-5p
Topotecan 60700 Drug interaction    RC00005069
Doxorubicin 31703 Drug interaction    RC00005068
Verapamil 2520 Drug interaction    RC00005067
Docetaxel 148124 Drug interaction    RC00005070
Chemotherapy - Drug interaction    RC00008866

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-431-5p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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