Detail Information

Basic Information:


  VIRBase ID:  

HVID00006376

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-346 ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0000773 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-346
rs1026858249 chr10:86264760    C/G
rs1026858249 chr10:86264760    C/T
rs1239349293 chr10:86264759    G/A
rs1310080313 chr10:86264769    A/G
rs1384729115 chr10:86264750    G/T
rs750124654 chr10:86264761    G/A
rs1329800845 chr10:86264764    C/G
rs1440341525 chr10:86264768    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-346
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-346
Gemcitabine 60750 Drug interaction    RC00004544
D-Glucose 5793 Drug interaction    RC00004542
Risperidone 5073 Drug interaction    RC00004541
Diethylstilbestrol 448537 Drug interaction    RC00004545
Paclitaxel 36314 Drug interaction    RC00004543
5-Fluorouracil 3385 Drug interaction    RC00004540
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004546
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-346
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-346
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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