Detail Information

Basic Information:


  VIRBase ID:  

HVID00006353

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-337-3p N
miRBase
Accession/Entrez ID		 MIMAT0000754 1489678
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sars9a

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-337-3p
rs1194699774 chr14:100874561    T/C
rs1211431443 chr14:100874571    C/G
rs1232445311 chr14:100874567    C/T
rs1252206634 chr14:100874574    C/A
rs1252206634 chr14:100874574    C/T
rs1273298357 chr14:100874562    G/A
rs1367433555 chr14:100874566    C/T
rs759642181 chr14:100874563    A/T
rs1268877469 chr14:100874558    A/G
rs1336886511 chr14:100874560    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-337-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-337-3p
8-Aminoadenosine 96851 Drug resistant
Actinomycin X4357G methoxime 9573583 Drug sensitive
1,9-Pyrazoloanthrone 8515 Drug resistant
Berberine iodide 72350 Drug sensitive
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Crotonoside 65085 Drug resistant
3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive
2-Azaadenine 5480214 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
Varacin trifluoroacetate salt 54611558 Drug resistant
2-Methylolivacinium acetate 5458752 Drug sensitive
Xestin A 5352066 Drug resistant
Berberal 5351462 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
6-Bromosangivamycin 470030 Drug resistant
Justicidin B 442882 Drug resistant
Suavedol 442245 Drug resistant
Musennin 441933 Drug sensitive
Isobrucein A 441802 Drug sensitive
Glaucarubinone 441796 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Haloprogin 3561 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Ellipticine 3213 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
Sarcoviolin 24202820 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
Kinetin riboside 20345 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug resistant
(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(3S)-5-[(2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid 152743331 Drug sensitive
(1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Acid Alizarine Red B 135565636 Drug sensitive
Formycin b 135449281 Drug resistant
Salicylidene salicylhydrazide 135445765 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
Berberine chloride 12456 Drug sensitive
Litmomycin 12310334 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant
Unii-9JU14BJ5QG 109374088 Drug sensitive
2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive
1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
2-bromo-3-ketocastanospermine - Drug resistant
granatomycin a - Drug resistant
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive
naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive
naphtho[2,1-b]quinolizinium, 7-methyl- chloride - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-(4-methylthio-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-methylellpticinium - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-337-3p
Hyaluronidase 91820602 Drug interaction    RC00004348
Gemcitabine 60750 Drug interaction    RC00004345
Estradiol 5757 Drug interaction    RC00004342
Diethylstilbestrol 448537 Drug interaction    RC00004347
Paclitaxel 36314 Drug interaction    RC00004344
Calcium sulfate 24497 Drug interaction    RC00004343
Docetaxel 148124 Drug interaction    RC00004346
Medpor - Drug interaction    RC00004349
Chemotherapy - Drug interaction    RC00008860
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-337-3p
Taxane 9548828       22723956
Cisplatin 5702198       30692017
Ifosfamide 3690       30692017
Paclitaxel 36314       22723956
Doxorubicin 31703       30692017
Methotrexate 126941       30692017
Cetuximab -       26107137
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-337-3p
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-337-3p
Interactor2: N

Evidence Support:


Prediction-Evidence IntaRNA//miRanda//miRTarP//psRNATarget
Support Database ViRBase

References:


[1]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).
[2]PMID 32765592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description From our rigorous analysis pipeline, which covers three different well-established algorithms (IntaRNA, miRanda, and psRNATarget) to predict RNA-RNA interactions, we have identified 122 and 106 host antiviral miRNAs against SARS-CoV (R) and SARS-CoV-2 (R), respectively (Figures 2A,B, Supplementary File 2).

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