Detail Information

Basic Information:


  VIRBase ID:  

HVID00006330

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-299-3p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0000687 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-299-3p
rs571491748 chr14:101023841    T/C
rs761962815 chr14:101023847    A/C
rs772505828 chr14:101023849    C/T
rs773042381 chr14:101023848    C/A
rs773714729 chr14:101023850    G/A
rs773714729 chr14:101023850    G/T
rs768725045 chr14:101023835    G/T
rs769090357 chr14:101023829    ATGTATG/A
rs954825951 chr14:101023839    G/A
rs954825951 chr14:101023839    G/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-299-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-299-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00003927
Gemcitabine 60750 Drug interaction    RC00003926
Vorinostat 5311 Drug interaction    RC00003924
Doxorubicin 31703 Drug interaction    RC00003925
Verapamil 2520 Drug interaction    RC00003923
Gefitinib 123631 Drug interaction    RC00003928
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003929
Chemotherapy - Drug interaction    RC00008854
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-299-3p
Doxorubicin 31703       26617714

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-299-3p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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