Detail Information

Basic Information:


  VIRBase ID:  

HVID00006192

  Virus:  

Porcine epidemic diarrhea virus CV777

  Host:  

Sus scrofa

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol ssc-miR-221-5p N
miRBase
Accession/Entrez ID		 ssc-miR-221-5p N
Organism Sus scrofa Porcine epidemic diarrhea virus CV777
Category miRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: ssc-miR-221-5p
Interactor2: N

Evidence Support:


Strong-Evidence IFA//qRT-PCR//Western blot
Prediction-Evidence ViTa
Support Database ViRBase

References:


PMID 30380612 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line MARC-145 cells Interactor2 expression None
Description MiR-221-5p directly targets the 3' untranslated region (UTR) of PEDV genomic RNA to inhibit PEDV replication;MiR-221-5p overexpression inhibited PEDV replication in a dose-dependent manner, and that silencing endogenous miR-221-5p enhanced viral replication.

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