Detail Information

Basic Information:


  VIRBase ID:  

HVID00006170

  Virus:  

Sindbis virus

  Host:  

Homo sapiens

  Confidence Score:  

0.9489

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-124-3p E1
miRBase
Accession/Entrez ID		 MIMAT0000422 E1
Organism Homo sapiens Sindbis virus
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-124-3p
rs1256263272 chr8:9903400    T/C
rs1482188536 chr8:9903410    C/A
rs753437646 chr8:9903401    G/T
rs759045572 chr8:9903402    G/T
rs764861083 chr8:9903408    A/G
rs759034202 chr8:64379220    G/A
rs1364752547 chr20:63178563    G/A
rs749909250 chr20:63178569    G/A
rs1287398108 chr20:63178559    C/G
rs34059726 chr20:63178555    G/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-124-3p
Exosome Plasma     23663360
Exosome Blood     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Urine     -
Mitochondrion Cell line (HEK-293)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-124-3p
N,N-Dimethyltryptamine 6089 Drug interaction    RC00002595
Estradiol 5757 Drug interaction    RC00002594
Vorinostat 5311 Drug interaction    RC00002593
Cocaine 446220 Drug interaction    RC00002602
Paroxetine 43815 Drug interaction    RC00002601
Methylphenidate 4158 Drug interaction    RC00002592
Methadone 4095 Drug interaction    RC00002591
Etoposide 36462 Drug interaction    RC00002600
Harmaline 3564 Drug interaction    RC00002603
Fluoxetine 3386 Drug interaction    RC00002590
Enoxacin 3229 Drug interaction    RC00002589
Doxorubicin 31703 Drug interaction    RC00002599
Desipramine 2995 Drug interaction    RC00002588
Camptothecin 24360 Drug interaction    RC00002598
Cobalt chloride (CoCl2) 24288 Drug interaction    RC00002597
N,N-Dimethyl-5-methoxytryptamine 1832 Drug interaction    RC00002587
Arsenic trioxide 14888 Drug interaction    RC00002596
IR - Drug interaction    RC00002604
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-124-3p
Doxorubicin 31703       30807260

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-124-3p
Interactor2: E1

Evidence Support:


Strong-Evidence Northern blot//Western blot
Weak-Evidence Small RNA sequencing
Prediction-Evidence ViTa
Support Database ViRBase

References:


PMID 32102877 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression None
Description Using the prediction algorithm ViTa (35), we found three putative binding sites at positions 2454 to 2475, 3828 to 3853, and 10904 to 10926 in the viral genome. We further studied the latter, localized within the virus ORF2, and more specifically, in the glycoprotein E1 coding region (Fig. 4A), which possesses a canonical 6-nucleotide (nt) seed match (nucleotides 2 to 7) for miR-124-3p.

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