Detail

Detail Information

Basic Information:

VIRBase ID:

HVID00006095

Virus:

Vesicular stomatitis Indiana virus (VSIV)

Host:

Mus musculus

Confidence Score:

0.7311

Interaction Type:

Host-Virus interaction

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-378a-3p	P
miRBase Accession/Entrez ID	MIMAT0003151	P
Organism	Mus musculus	Vesicular stomatitis Indiana virus (VSIV)
Category	miRNA	protein
Alias	-	-

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

mmu-miR-378a-3p

Exosome	Mast cells	17486113
Exosome	B6 BMDCs	22031862
Mitochondrion	Heart tissue (subsarcolemmal and interfibrillar)	26377859
Nucleus	Liver cells	21862971

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-378a-3p

Interactor2: P

Evidence Support:

Strong-Evidence	Luciferase reporter assay
Support Database	VmiReg

References:

PMID	17613256	Target region	None
Source	VmiReg	Interactor1 expression	None
Tissue or cell line	RAW 264.7 cells	Interactor2 expression	None
Description	Rather, we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein (P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells. Our data suggest that host miRNA can play a role in host interactions with viruses. Plaque-purified VSV (Indiana strain) and Vaccinia virus (vTF7-3) was also described previously.

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