Detail Information

Basic Information:


  VIRBase ID:  

HVID00006093

  Virus:  

Vesicular stomatitis Indiana virus (VSIV)

  Host:  

Mus musculus

  Confidence Score:  

0.9070

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol mmu-miR-24-3p L
miRBase
Accession/Entrez ID		 MIMAT0000219 L
Organism Mus musculus Vesicular stomatitis Indiana virus (VSIV)
Category miRNA protein
Alias - -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate mmu-miR-24-3p
Axon DRG neurons     24381269
Exosome Conditioned medium of E13 SMG     28041903
Exosome Serum     28160157
Exosome Mast cells     17486113
Exosome B6 BMDCs     22031862
Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126
Exosome Bone marrow-derived macrophages     25159140
Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859
Nucleus Spermatocytes     18204908
Nucleus Liver cells     21862971

Interaction Network (The top 100 interactions):


Interactor1: mmu-miR-24-3p
Interactor2: L

Evidence Support:


Strong-Evidence Luciferase reporter assay//Western blot
Prediction-Evidence DIANA-microT//MicroInspector
Support Database ViRBase//VmiReg

References:


PMID 17613256 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line Dicer1(d/d) cells//RAW 264.7 cells Interactor2 expression Downregulation
Description Rather, we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein (P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells. Our data suggest that host miRNA can play a role in host interactions with viruses. Plaque-purified VSV (Indiana strain) and Vaccinia virus (vTF7-3) was also described previously.

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