Detail Information

Basic Information:


  VIRBase ID:  

HVID00006092

  Virus:  

Vesicular stomatitis Indiana virus (VSIV)

  Host:  

Mus musculus

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol mmu-miR-146a-5p P
miRBase
Accession/Entrez ID		 MIMAT0000158 P
Organism Mus musculus Vesicular stomatitis Indiana virus (VSIV)
Category miRNA protein
Alias - -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate mmu-miR-146a-5p
Exosome Bone marrow-derived dendritic cells     26084661
Exosome Serum     28160157
Exosome B6 BMDCs     22031862
Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126
Exosome Bone marrow-derived macrophages     25159140
Exosome mBMSCs     33658070
Extracellular vesicle Dendritic cells|T cells     22821563
Mitochondrion Hippocampus neuron     27396686
Mitochondrion Liver tissue     20733615
Mitochondrion Hippocampus     25562527
Synaptoneurosome ForeBrain     18410515

Interaction Network (The top 100 interactions):


Interactor1: mmu-miR-146a-5p
Interactor2: P

Evidence Support:


Strong-Evidence Luciferase reporter assay
Support Database VmiReg

References:


PMID 17613256 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line RAW 264.7 cells Interactor2 expression None
Description Rather, we found that host miR24 and miR93 could target viral large protein(L protein) and phosphoprotein (P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells. Our data suggest that host miRNA can play a role in host interactions with viruses. Plaque-purified VSV (Indiana strain) and Vaccinia virus (vTF7-3) was also described previously.

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