Basic Information:

  VIRBase ID:  

HVID00006071

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Rattus norvegicus

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Virus interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   tat:  NP_057853     

Binding sites in PDB
PDB	3MI9//3MIA//4OR5

Interactor Information:

	Interactor1	Interactor2
Symbol	rno-miR-25-3p	tat
miRBase Accession/Entrez ID	MIMAT0000795	155871
Organism	Rattus norvegicus	Human immunodeficiency virus 1 (HIV-1)
Category	miRNA	protein
Alias	-	HIV1gp5

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	rno-miR-25-3p	Axon Sympathetic neurons     20584895 Cytoplasm L6 myoblasts     19628621 Nucleus Cortical cells|Hippocampal neurons     24324399

Interaction Network (The top 100 interactions):

Interactor1: rno-miR-25-3p
Interactor2: tat

Evidence Support:

Strong-Evidence	IHC//qRT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	ViRBase

References:

[1]PMID	18381601	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	293T cells	Interactor2 expression	None
Description	These are designated 128a, 128b, 100, 99a, 30b, 30c, let-7c, let-7f, let-7b, let-7e, 125a, 125b, 191, 181a, and 9. A group of six microRNAs (374, 128a, 128b, 100, 25, and 99a) was upregulated in Tat-treated samples (mean fold change from 4. 4 to 1. 5; P-value <0. 01). The presence of Tat in neurons also determined a downregulation of seven microRNAs: let-7e, 298, let-7f, let-7c, let-7b, 320, and 214. The expression pattern of a third group of microRNAs (125a, 92, 30c, 99b, 125b, 181a, 191, and 9) was not changed by Tat-treatment.

[2]PMID	21786074	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	293T cells	Interactor2 expression	None
Description	Eletto and colleagues reported that a group of six miRNAs (374, 128a, 128b, 100, 25, and 99a) were upregulated and seven miRNAs (let-7e, 298, let-7f, let-7c, let-7b, 320, and 214) were downregulated by Tat in rat primary cortical neurons. Among these, miR-128a has been found to be enriched in the brain, preferentially in the mature neurons.