Detail Information

Basic Information:


  VIRBase ID:  

HVID00005946

  Virus:  

Human papillomavirus type 18

  Host:  

Homo sapiens

  Confidence Score:  

0.9490

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-5p E6
miRBase
Accession/Entrez ID		 MIMAT0000098 1489088
Organism Homo sapiens Human papillomavirus type 18
Category miRNA mRNA
Alias - HpV18gp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-5p
rs1040212796 chr11:122152283    C/T
rs1412200886 chr11:122152286    A/T
rs760833074 chr11:122152288    C/CTACG
rs761222509 chr11:122152284    G/A
rs764595517 chr11:122152287    T/A
rs764595517 chr11:122152287    T/C
rs775920236 chr11:122152275    C/T
rs1200346714 chr11:122152292    G/A
rs777169031 chr11:122152293    G/A
rs899939219 chr11:122152291    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome LAC cell line (A549)     28553110
Exosome Primary dendritic cells     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Breast tissue|Colon tissue|Endothelial cells|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-100-5p
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Pingyangmycin 84046 Drug sensitive
Mevastatin 64715 Drug sensitive
Selendale 54601159 Drug sensitive
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
Simvastatin 54454 Drug sensitive
Heliangolide 5384466 Drug resistant
Lovastatin 53232 Drug sensitive
Patulin 4696 Drug resistant
Adaphostin 387042 Drug resistant
(3R,5S)-Fluvastatin(1-) 37888681 Drug sensitive
2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]-4-methylidenepentanedioic acid 375312 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug sensitive
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug sensitive
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
ERB-38 Immunotoxin - Drug resistant
organosulfur compound - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
active compound from cephalodiscus gilchristi - Drug sensitive
atorvastatin calcium (usan) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-100-5p
Formaldehyde 712 Drug interaction    RC00001069
Everolimus 6442177 Drug interaction    RC00001091
Aniline 6115 Drug interaction    RC00001075
Gemcitabine 60750 Drug interaction    RC00001082
Vincristine 5978 Drug interaction    RC00001074
Prednisolone 5755 Drug interaction    RC00001073
Eloxatine 5310940 Drug interaction    RC00001090
Sirolimus 5284616 Drug interaction    RC00001089
Goserelinacetate 47725 Drug interaction    RC00001081
Trichostatin A 444732 Drug interaction    RC00001087
Vemurafenib 42611257 Drug interaction    RC00001093
Etoposide 36462 Drug interaction    RC00001080
Paclitaxel 36314 Drug interaction    RC00001079
Doxorubicin 31703 Drug interaction    RC00001078
Daunorubicin 30323 Drug interaction    RC00001077
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001072
Tamoxifen 2733526 Drug interaction    RC00001088
Verapamil 2520 Drug interaction    RC00001071
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001092
Bicalutamide 2375 Drug interaction    RC00001070
Sorafenib 216239 Drug interaction    RC00001086
Arsenic trioxide 14888 Drug interaction    RC00001076
Docetaxel 148124 Drug interaction    RC00001085
Gefitinib 123631 Drug interaction    RC00001084
Ginsenoside Rh2 119307 Drug interaction    RC00001083
Asparaginase Escherichia coli - Drug interaction    RC00001094
TRAIL therapy - Drug interaction    RC00001095
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001096
Glucocorticoid - Drug interaction    RC00001097
Trastuzumab - Drug interaction    RC00001098
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-5p
Lorlatinib 71731823       30791979
Cisplatin 5702198       26676926
Cisplatin 5702198       28553110
Doxorubicin 31703       24759738
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Crizotinib 11626560       30791979

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-5p
Interactor2: E6

Evidence Support:


Strong-Evidence Northern blot//TaqMan qRT-PCR
Weak-Evidence Microarray//MiRNA sequencing
Support Database ViRBase

References:


PMID 24591631 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HFKs cells//HVK cells Interactor2 expression None
Description These observations validated the specificity of E6 and E7 activities. In addition, HPV18 E7 had a stronger positive effect than HPV18 E6 on the expression of miR-16 and miR-378, whereas both viral oncoproteins functioned similarly in inducing a moderate increase of miR-92a expression (Fig. 3). Interestingly, miR-22, miR-27a, miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6 (Fig. 3).

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