Detail Information

Basic Information:


  VIRBase ID:  

HVID00005940

  Virus:  

Human papillomavirus type 18

  Host:  

Homo sapiens

  Confidence Score:  

0.9490

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27a-3p E6
miRBase
Accession/Entrez ID		 MIMAT0000084 1489088
Organism Homo sapiens Human papillomavirus type 18
Category miRNA mRNA
Alias - HpV18gp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27a-3p
rs1017144560 chr19:13836448    C/T
rs1229675567 chr19:13836450    G/A
rs1357673449 chr19:13836458    C/T
rs1427981338 chr19:13836447    G/T
rs775828465 chr19:13836449    G/A
rs973512467 chr19:13836453    C/G
rs973512467 chr19:13836453    C/T
rs1222227623 chr19:13836466    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27a-3p
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Cell lines (MCF10A|MCF-7|MDA-MB-231)     25446899
Exosome Glioblastoma cells     19011622
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Glioblastoma cells     19011622
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-27a-3p
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
Heliangolide 5384466 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Herbimycin 5311102 Drug resistant
Eupachlorin 5281446 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Benzoxazole, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 364608 Drug resistant
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
Discorhabdin C-nitrodienone . TFA 362394 Drug resistant
Pyrazoloacridine 339455 Drug resistant
Predorine 333830 Drug resistant
Benzofurazan, 4-[(3-methoxyphenyl)thio]-7-nitro-, 3-oxide 313591 Drug resistant
Dichloroallyl lawsone 277767 Drug resistant
2,4,6-Trichloro-5-methylpyrimidine 232789 Drug resistant
8-Hydroxyquinoline 1923 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
N-[3-[(3-Amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1S)-18-[(2S)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide 146156820 Drug resistant
1,8-naphthyridin-3-amine, 2,7-dichloro-5-methyl- - Drug resistant
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug resistant
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
pneumocandin b(sub 0) - Drug resistant
Tetraplatin - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27a-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00000818
Curcumin 969516 Drug interaction    RC00000825
Bilobalide 73581 Drug interaction    RC00000817
Formaldehyde 712 Drug interaction    RC00000803
Gemcitabine 60750 Drug interaction    RC00000816
Cholesterol 5997 Drug interaction    RC00000810
Vincristine 5978 Drug interaction    RC00000809
Estradiol 5757 Drug interaction    RC00000808
Dexamethasone 5743 Drug interaction    RC00000807
Eloxatine 5310940 Drug interaction    RC00000828
Genistein 5280961 Drug interaction    RC00000827
Decitabine 451668 Drug interaction    RC00000824
Trichostatin A 444732 Drug interaction    RC00000823
Bortezomib 387447 Drug interaction    RC00000822
Hydroxyurea 3657 Drug interaction    RC00000806
Paclitaxel 36314 Drug interaction    RC00000815
5-Fluorouracil 3385 Drug interaction    RC00000805
Doxorubicin 31703 Drug interaction    RC00000814
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000804
Tamoxifen 2733526 Drug interaction    RC00000826
Calcium sulfate 24497 Drug interaction    RC00000813
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000829
Arsenic trioxide 14888 Drug interaction    RC00000812
Docetaxel 148124 Drug interaction    RC00000821
2-Fluoropyrimidine 141643 Drug interaction    RC00000820
Vinblastine 13342 Drug interaction    RC00000811
Methotrexate 126941 Drug interaction    RC00000819
SIOP treatment protocol - Drug interaction    RC00000830
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00000831
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000832
Aidi injection - Drug interaction    RC00000833
Chemotherapy - Drug interaction    RC00008823
Berbamine derivative(BBMD3) - Drug interaction    RC00000834
Bio-Oss - Drug interaction    RC00000835
Glucocorticoid - Drug interaction    RC00000836
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000837
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27a-3p
Quisinostat 11538455       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27a-3p
Interactor2: E6

Evidence Support:


Strong-Evidence Northern blot//TaqMan qRT-PCR
Weak-Evidence Microarray//MiRNA sequencing
Support Database ViRBase

References:


PMID 24591631 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HFKs cells//HVK cells Interactor2 expression None
Description These observations validated the specificity of E6 and E7 activities. In addition, HPV18 E7 had a stronger positive effect than HPV18 E6 on the expression of miR-16 and miR-378, whereas both viral oncoproteins functioned similarly in inducing a moderate increase of miR-92a expression (Fig. 3). Interestingly, miR-22, miR-27a, miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6 (Fig. 3).

Starting a new search, please wait ...