Detail Information

Basic Information:


  VIRBase ID:  

HVID00005937

  Virus:  

Human papillomavirus type 18

  Host:  

Homo sapiens

  Confidence Score:  

0.9490

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-22-3p E6
miRBase
Accession/Entrez ID		 MIMAT0000077 1489088
Organism Homo sapiens Human papillomavirus type 18
Category miRNA mRNA
Alias - HpV18gp1

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-22-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-22-3p
Piperidine, 2-methyl-6-undecyl- 99090 Drug resistant
Gardenin B 96539 Drug resistant
Ambrosin 92119 Drug resistant
Terreic acid 91437 Drug resistant
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug sensitive
Morpholine-N-dithiocarbamate 72675 Drug resistant
7-Hydroxystaurosporine 72271 Drug resistant
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug resistant
Edatrexate 6917908 Drug resistant
Phosphotrienin 6913994 Drug resistant
Sulbentine 67686 Drug resistant
Silver mesylate 6712944 Drug resistant
Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug resistant
Acnistin F 6712173 Drug resistant
Reactive Blue 2 656725 Drug resistant
Mevastatin 64715 Drug sensitive
Flexibilide 6438436 Drug resistant
Verrucarin A 6326658 Drug resistant
Jatrophon 6325446 Drug resistant
Chalcone analog 6296717 Drug resistant
[(2Z)-12-Hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (E)-2-methylbut-2-enoate 5477565 Drug resistant
Caracemide 54747 Drug resistant
Artelasticin 5471311 Drug resistant
(Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
Antineoplastic-651590 54604785 Drug resistant
Selendale 54601159 Drug sensitive
Aspiculamycin hcl 54600418 Drug sensitive
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
Cuspidatin C 5459164 Drug resistant
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug resistant
Thiram 5455 Drug resistant
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug resistant
Heliangolide 5384466 Drug resistant
Acetylrolandrolide 5384465 Drug resistant
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug resistant
Melampodin B acetate 5359212 Drug resistant
Lobolide 5359032 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Crassin, acetate 5355441 Drug resistant
5-[6-[(1-Methylpiperidin-4-yl)methoxy]benzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338689 Drug resistant
Herbimycin 5311102 Drug resistant
Plumericin 5281545 Drug resistant
Eupachlorin 5281446 Drug resistant
Erioflorin acetate 5281443 Drug resistant
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug resistant
Lychnopholide 49767028 Drug resistant
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug resistant
6-Bromosangivamycin 470030 Drug resistant
Patulin 4696 Drug resistant
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Kalamycin 443836 Drug resistant
Fastigilin B 442241 Drug resistant
Elephantopin 442206 Drug resistant
Elephantin 442205 Drug resistant
Iproplatin 44214 Drug resistant
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
Nanaomycin A 40586 Drug resistant
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug resistant
15-Oxozoapatlin 391317 Drug resistant
5,8-Quinolinedione, 2-methyl- 388305 Drug resistant
Adaphostin 387042 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
4-Azido-2-chloro-3-cyanoquinoline 381915 Drug resistant
1-Azido-2-formyl-benzo[ij]quinolizin-3-one 381901 Drug resistant
2-Chloro-3-(1-(4-methyl)piperazino)naphthazarin 378627 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant
5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug resistant
Cycloalkannin 375418 Drug resistant
N-Hydroxy-N-methylpropanethioamide 371713 Drug resistant
11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug resistant
Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug resistant
Benzoxazole, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 364608 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
3-Nitro-5-formylisoxazole 362479 Drug resistant
Discorhabdin C-nitrodienone . TFA 362394 Drug resistant
Discorhabdin C . TFA 362393 Drug resistant
2-Hydroxy discorhabdin D 362391 Drug resistant
7,12-Epidioxybenz[a]anthracene, 7,12-dihydro-7-methyl- 362095 Drug resistant
4H-1-Benzothiopyran-4-one, 2-(methylsulfinyl)- 360259 Drug resistant
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Thiosangivamycin 3580213 Drug resistant
Haloprogin 3561 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
Bis(helenalinyl)glutarate 336831 Drug resistant
Rustaiyan A 324967 Drug resistant
Dmask 32465 Drug resistant
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug resistant
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug resistant
6-(Dimethylarsanylsulfanylmethyl)oxane-2,3,4,5-tetrol 311912 Drug resistant
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug resistant
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
4-[3-[2-Chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]propanoylamino]benzenesulfonyl fluoride;ethanesulfonic acid 276171 Drug resistant
2-Hydroxy-4-((2,4,6-triamino-5-pyrimidinyl)diazenyl)phenylarsonic acid 272658 Drug resistant
Chelerythrine 2703 Drug resistant
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug resistant
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
Antibiotic U 29135 24196291 Drug resistant
Cytembena 23665583 Drug resistant
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug resistant
Drostanolone propionate 224004 Drug resistant
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant
8-Hydroxyquinoline 1923 Drug resistant
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug resistant
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug resistant
Paucin 161538 Drug resistant
(3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug resistant
(6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
Methyl 3,4-dichloro-5-nitro-2-furoate 147711 Drug resistant
8-Chloroadenosine 147569 Drug resistant
4-Oxo-4-[[(13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid 146160078 Drug resistant
1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug resistant
Methyl (7E,9Z,11R,12S,13R,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-12,14,18,19,31-pentahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319083 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Discorhabdin B 135409044 Drug resistant
2-Chloro-3-(2-butoxyethoxy)naphthazarin 135406263 Drug resistant
Inosine dialdehyde 135400916 Drug resistant
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant
Triphenyltin chloride 12540 Drug resistant
Benzyl trisulfide 122842 Drug resistant
2-Chloro-3-(phenylsulfonyl)propanenitrile 121458 Drug resistant
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant
Cytochalasin q 11970174 Drug resistant
Melampodinin 11953936 Drug resistant
p-Toluquinone 11122 Drug resistant
2,9-Dimethylellipticinium acetate 10472068 Drug sensitive
9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug resistant
Chimaphilin 101211 Drug resistant
Cyanocycline A 100158 Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug resistant
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug resistant
1,3,5-triazin-2-amine, 4,6-dimethoxy-n-phenyl- - Drug resistant
1,3-butadiene, 1,1,2,4,4-pentachloro-3-nitro- - Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug resistant
1-piperidinecarbodithioic acid, antimony complex - Drug resistant
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug resistant
2-azabicyclo[16.3.1]docosane, geldanamycin deriv. - Drug resistant
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant
4-thiomorpholinecarbodithioic acid, antimony complex - Drug resistant
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug resistant
7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug resistant
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug resistant
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug resistant
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug resistant
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
geldanamycin, n,n'-dimethyl - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-propyl- - Drug resistant
sp-adenosine-3',5'-cyclic phosphorothioate - Drug resistant
thymine, 1,3-bis[1,2-bis(ethoxycarbonyl)ethenyl]- - Drug resistant
uracil, 1,3-bis[1,2-bis(ethoxycarbonyl)ethenyl]- - Drug resistant
uridine, 5-isobutyl-2'-deoxy- - Drug resistant
10-hydroxy-scandine - Drug resistant
antineoplastic-d183258 - Drug resistant
antineoplastic-d665827 - Drug resistant
bis(2-nitrophenyl)sulfilimine - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
geldanamycin analog - Drug resistant
granatomycin a - Drug resistant
methyl 3-farnesylthioacetate - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
obtained by culturing a strain of micromonospora - Drug resistant
secafascaplysin - Drug resistant
somatostatin analog in diacetic form mw=1067.2 - Drug resistant
streptorubrin - Drug resistant
Tetraplatin - Drug resistant
thiadiazines - Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
2-methylellpticinium - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-22-3p
Curcumin 969516 Drug interaction    RC00000666
Oxaliplatine 6857599 Drug interaction    RC00000668
Gemcitabine 60750 Drug interaction    RC00000659
Testosterone 6013 Drug interaction    RC00000652
Vincristine 5978 Drug interaction    RC00000651
Estradiol 5757 Drug interaction    RC00000650
Mitomycin 5746 Drug interaction    RC00000649
Cholecalciferol 5280795 Drug interaction    RC00000667
Decitabine 451668 Drug interaction    RC00000665
Diethylstilbestrol 448537 Drug interaction    RC00000664
Tretinoin 444795 Drug interaction    RC00000662
Trichostatin A 444732 Drug interaction    RC00000661
Carboplatinum 38904 Drug interaction    RC00000658
Paclitaxel 36314 Drug interaction    RC00000657
5-Fluorouracil 3385 Drug interaction    RC00000648
Doxorubicin 31703 Drug interaction    RC00000656
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000647
Calcium sulfate 24497 Drug interaction    RC00000655
Arsenic trioxide 14888 Drug interaction    RC00000654
Pemetrexed 135410875 Drug interaction    RC00000663
Leucovorin 135403648 Drug interaction    RC00000669
Gefitinib 123631 Drug interaction    RC00000660
Androstanolone 10635 Drug interaction    RC00000653
Chemotherapy - Drug interaction    RC00008819
Neomycin - Drug interaction    RC00000670
Trastuzumab - Drug interaction    RC00000671
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000672
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000673
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00000674
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-22-3p
Gemcitabine 60750       29620229
Cisplatin 5702198       29620229
(7S,9S)-7-[(2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydron;chloride 53630345       29620229
Paclitaxel 36314       29620229
Doxorubicin 31703       29620229
CID 14440697 14440697       29620229
(9S)-7-[(2R)-4-Amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 137704806       29620229

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-22-3p
Interactor2: E6

Evidence Support:


Strong-Evidence Northern blot//TaqMan qRT-PCR
Weak-Evidence Microarray//MiRNA sequencing
Support Database ViRBase

References:


PMID 24591631 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HFKs cells//HVK cells Interactor2 expression None
Description These observations validated the specificity of E6 and E7 activities. In addition, HPV18 E7 had a stronger positive effect than HPV18 E6 on the expression of miR-16 and miR-378, whereas both viral oncoproteins functioned similarly in inducing a moderate increase of miR-92a expression (Fig. 3). Interestingly, miR-22, miR-27a, miR-29a, and miR-100 were all moderately down-regulated by either E6 or E7, with miR-22 and miR-27a being slightly more susceptible to E7 than to E6 (Fig. 3).

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