Detail Information

Basic Information:


  VIRBase ID:  

HVID00005926

  Virus:  

Human papillomavirus type 16 (HPV16)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-203a-3p E6
miRBase
Accession/Entrez ID		 MIMAT0000264 1489078
Organism Homo sapiens Human papillomavirus type 16 (HPV16)
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-203a-3p
rs1233551988 chr14:104117478    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-203a-3p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|Breast tissue|Colon tissue|Seminal fluid|Tongue tissue     -
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Breast cell line|Colon cancer cell line (LIM1863)|Urine     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-203a-3p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug resistant
Midostaurin 9829523 Drug resistant
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant
Pingyangmycin 84046 Drug resistant
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug resistant
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug sensitive
10,11-Methylenedioxy-20S-camptothecin 72403 Drug resistant
7-Hydroxystaurosporine 72271 Drug resistant
(9S)-7-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-9-(2-fluoroacetyl)-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione 6711360 Drug resistant
Fludarabine 657237 Drug resistant
Neocuproine 65237 Drug sensitive
Crotonoside 65085 Drug sensitive
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive
Mevastatin 64715 Drug resistant
Psammaplin A 6400741 Drug resistant
Chalcone analog 6296717 Drug sensitive
Methylene blue 6099 Drug sensitive
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-(1H-pyrrol-2-yl)thieno[3,2-d]pyrimidin-4-amine;hydrochloride 57401575 Drug sensitive
Cisplatin 5702198 Drug resistant
12,13-Dihydro-3,9-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione 5482344 Drug resistant
Thiopyrimidine-OCH3 5473172 Drug sensitive
Tetrocarcin A, sodium salt 54724658 Drug resistant
(Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug resistant
Bleomycin 5460769 Drug resistant
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
[2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug resistant
Simvastatin 54454 Drug resistant
Hemiasterlin 5352092 Drug sensitive
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive
Hydroxy AT 125 5351254 Drug sensitive
Reumycin 5351216 Drug resistant
Lovastatin 53232 Drug resistant
Alvocidib 5287969 Drug resistant
8-Hydroxymanzamine A 5270765 Drug sensitive
Guanosine,3',5'-tripropanoate 5035970 Drug resistant
Staurosporine, 98% 49831000 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug sensitive
Hookerianamide I 44587245 Drug sensitive
Musennin 441933 Drug resistant
Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive
Trichopolyn 431962 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Carboplatin 426756 Drug resistant
Diaziquone 42616 Drug resistant
cis-Diamminemalonatoplatinum(II) 422683 Drug resistant
Aminopyrimidine-F 406276 Drug sensitive
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug resistant
(2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive
Sjg-136 393111 Drug resistant
3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug sensitive
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug sensitive
Cycloalkannin 375418 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
Discorhabdin C-nitrodienone . TFA 362394 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Pdtpt 357140 Drug resistant
Buellolide 337850 Drug sensitive
Ellipticine 3213 Drug sensitive
Phomazarin 318385 Drug resistant
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
AT 116, benzylamine salt 282523 Drug resistant
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug resistant
Haterumalide NA methyl esters 24204452 Drug resistant
3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Trihexyltetradecylphosphonium tetrafluoroborate 16211343 Drug resistant
Jolkinolide B 161954 Drug resistant
O-Desmethylbouvardin 160296 Drug resistant
Acrovestone 159969 Drug sensitive
4-Oxo-4-[[(13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid 146160078 Drug sensitive
Strospeside, 16-acetate (6CI,7CI,8CI); (3beta,5beta,16beta)-16-(Acetyloxy)-3-[(6-deoxy-3-O-methyl-beta-D-galactopyranosyl)oxy]-14-hydroxycard-20(22)-enolide 146158929 Drug resistant
8-Azahypoxanthine 135410720 Drug resistant
8-Azaguanine 135403646 Drug resistant
Inosine dialdehyde 135400916 Drug sensitive
DTIC-Dome 135398738 Drug resistant
43-Dioxypectenotoxin 131751434 Drug resistant
Saintopin 131350 Drug resistant
Pepleo 122804 Drug resistant
(5S,7S)-5,7,9,10-Tetrahydroxy-2-methoxy-7-methyl-6,8-dihydro-5H-anthracene-1,4-dione 11209399 Drug sensitive
Capri Blue 102162 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
Clomesone 100651 Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug resistant
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug resistant
piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant
(-)-furodysinin - Drug resistant
2-(n-d-glysoyl)aminobenzothiazole - Drug resistant
6-nitro-1-indazolecarboxy-4'-chloro-2'-anisidide - Drug resistant
active compound from cephalodiscus gilchristi - Drug resistant
allylgutimine - Drug resistant
Annamycin Liposomal - Drug resistant
atorvastatin calcium (usan) - Drug resistant
Camptothecin Derivative - Drug resistant
Chlorozotocin - Drug resistant
CI-921: amsacrine derivative - Drug resistant
crotoxin cd - Drug resistant
hymenialdisine - Drug resistant
Indenoisoquinoline derivative - Drug resistant
orlistat (usan) - Drug resistant
potassium arsenite - Drug resistant
potassium[trichloro(isopropylamine)platinum] - Drug resistant
protein toxin a 23 - mw approx. 6700 - Drug resistant
protein toxin c 10 - mw approx. 6700 - Drug resistant
protein: pahiv4 - Drug resistant
trimethyl(phenylthio)stannane - Drug resistant
tunicamycin - Drug resistant
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug sensitive
uridine, 5-fluoro-, 2',3',5'-triacetate - Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug sensitive
antineoplastic-625543 - Drug sensitive
antineoplastic-641297 - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
ERB-38 Immunotoxin - Drug sensitive
granatomycin a - Drug sensitive
ovb3-pe - Drug sensitive
secafascaplysin - Drug sensitive
tgf.alpha.-pe40 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-203a-3p
Curcumin 969516 Drug interaction    RC00001967
Azacitidine 9444 Drug interaction    RC00001956
Hyaluronidase 91820602 Drug interaction    RC00001971
Gemcitabine 60750 Drug interaction    RC00001963
Vincristine 5978 Drug interaction    RC00001955
D-Glucose 5793 Drug interaction    RC00001954
Estradiol 5757 Drug interaction    RC00001953
Prednisolone 5755 Drug interaction    RC00001952
Temozolomide 5394 Drug interaction    RC00001951
Eloxatine 5310940 Drug interaction    RC00001970
Imatinib 5291 Drug interaction    RC00001950
Cholecalciferol 5280795 Drug interaction    RC00001969
Goserelinacetate 47725 Drug interaction    RC00001962
Diethylstilbestrol 448537 Drug interaction    RC00001966
Paclitaxel 36314 Drug interaction    RC00001961
5-Fluorouracil 3385 Drug interaction    RC00001949
Doxorubicin 31703 Drug interaction    RC00001960
Daunorubicin 30323 Drug interaction    RC00001959
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001948
Tamoxifen 2733526 Drug interaction    RC00001968
Cadmium 23973 Drug interaction    RC00001958
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine 2051 Drug interaction    RC00001947
Canertinib dihydrochloride 156413 Drug interaction    RC00001965
Arsenic trioxide 14888 Drug interaction    RC00001957
Docetaxel 148124 Drug interaction    RC00001964
Asparaginase Escherichia coli - Drug interaction    RC00001972
Estrogen - Drug interaction    RC00001973
Glucocorticoid - Drug interaction    RC00001974
Interleukin 13 (IL-13) - Drug interaction    RC00001975
Marine fungal metabolite 1386A - Drug interaction    RC00001976
Phorbol ester TPA - Drug interaction    RC00001977
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-203a-3p
Cisplatin 5702198       30692017
Ifosfamide 3690       30692017
Doxorubicin 31703       30692017
Methotrexate 126941       30692017

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-203a-3p
Interactor2: E6

Evidence Support:


Strong-Evidence Northern blot//RQ-PCR//RT-PCR//Western blot
Support Database ViRBase

References:


PMID 20702634 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line H1299 cells//HFKs cells Interactor2 expression Downregulation
Description We report that proliferation of HFKs is dependent on the level of miR-203 expression and that overexpression of miR-203 can reduce overproliferation in E6/E7-expressing and p53i HFKs. In summary, these results indicate that expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes.

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