Detail Information

Basic Information:


  VIRBase ID:  

HVID00005893

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1978 NS1
miRBase
Accession/Entrez ID		 MIMAT0009453 956533
Organism Homo sapiens Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Category miRNA mRNA
Alias - FLUAVs8gp2

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1978
Mitochondrion HeLa cells     27396686
Mitochondrion Cell line (HeLa)     21695135

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1978
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Dovitinib       135398510

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1978
Interactor2: NS1

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//RT-PCR
Support Database VIRmiRNA

References:


PMID WO_2010_101663_A2 Target region CDS
Source VIRmiRNA Interactor1 expression None
Tissue or cell line A549 cells//HEK293T cells Interactor2 expression None
Description The nucleic acid molecule of claim 22 or 25, wherein the MRE corresponds to miRNA selected from the group consisting of miR-16, miR-17, miR-19, miR-25, miR-34, miR-92, miR-93, miR-222, miR-149, miR-1977, miR-181b-2, miR-1259, and miR-1978. The nucleic acid molecule of claim 22, wherein the influenza virus coding sequence encodes an influenza virus protein selected from the group consisting of PBl, PB2, PA, Ml, M2, NP, NSl , and NS2/NEP. An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3' untranslated region (3' UTR) comprising one or more microRNA Response Element (MRE) sequences inserted between the stop codon of the transcript and the polyadenylation site.

Starting a new search, please wait ...