Detail Information

Basic Information:


  VIRBase ID:  

HVID00005831

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-34b-5p NS1
miRBase
Accession/Entrez ID		 MIMAT0000685 956533
Organism Homo sapiens Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Category miRNA mRNA
Alias - FLUAVs8gp2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-34b-5p
rs1017504405 chr11:111512961    A/C
rs1017504405 chr11:111512961    A/T
rs1203956425 chr11:111512967    T/A
rs1445025874 chr11:111512966    C/G
rs754923829 chr11:111512971    T/C
rs897516946 chr11:111512966    CT/C
rs964392295 chr11:111512969    A/T
rs1446235325 chr11:111512954    C/T
rs751488269 chr11:111512951    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-34b-5p
Exosome Primary dendritic cells     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Skeletal muscle myoblasts     21637849

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-34b-5p
4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 66718 Drug sensitive
Ferric-taxol 54612932 Drug resistant
Acronycine, 2-nitro 342903 Drug sensitive
L-Cysteine, S-[bis(4-methylphenyl)phenylmethyl]- 275979 Drug resistant
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug resistant
9-methoxy-5-hydroxycamptothecin - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-34b-5p
Curcumin 969516 Drug interaction    RC00003903
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003902

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-34b-5p
Interactor2: NS1

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//RT-PCR
Support Database VIRmiRNA

References:


PMID WO_2010_101663_A2 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line A549 cells//HEK293T cells Interactor2 expression None
Description The nucleic acid molecule of claim 22 or 25, wherein the MRE corresponds to miRNA selected from the group consisting of miR-16, miR-17, miR-19, miR-25, miR-34, miR-92, miR-93, miR-222, miR-149, miR-1977, miR-181b-2, miR-1259, and miR-1978. The nucleic acid molecule of claim 22, wherein the influenza virus coding sequence encodes an influenza virus protein selected from the group consisting of PBl, PB2, PA, Ml, M2, NP, NSl , and NS2/NEP. An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3' untranslated region (3' UTR) comprising one or more microRNA Response Element (MRE) sequences inserted between the stop codon of the transcript and the polyadenylation site.

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