Detail Information

Basic Information:


  VIRBase ID:  

HVID00005820

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-149-5p M2
miRBase
Accession/Entrez ID		 MIMAT0000450 956528
Organism Homo sapiens Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Category miRNA mRNA
Alias - FLUAVs7gp2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-149-5p
rs773885113 chr2:240456037    C/T
rs901919526 chr2:240456023    C/T
rs998903950 chr2:240456024    G/A
rs998903950 chr2:240456024    G/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-149-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Endothelial cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-149-5p
Gemcitabine 60750 Drug interaction    RC00003170
Temozolomide 5394 Drug interaction    RC00003165
Goserelinacetate 47725 Drug interaction    RC00003169
Bortezomib 387447 Drug interaction    RC00003173
Paclitaxel 36314 Drug interaction    RC00003168
5-Fluorouracil 3385 Drug interaction    RC00003164
Doxorubicin 31703 Drug interaction    RC00003167
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003163
Tamoxifen 2733526 Drug interaction    RC00003174
Bicalutamide 2375 Drug interaction    RC00003162
Arsenic trioxide 14888 Drug interaction    RC00003166
Docetaxel 148124 Drug interaction    RC00003172
Methotrexate 126941 Drug interaction    RC00003171
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003175
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-149-5p
Cisplatin 5702198       29393390

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-149-5p
Interactor2: M2

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//RT-PCR
Support Database VIRmiRNA

References:


PMID WO_2010_101663_A2 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line A549 cells//HEK293T cells Interactor2 expression None
Description The nucleic acid molecule of claim 22 or 25, wherein the MRE corresponds to miRNA selected from the group consisting of miR-16, miR-17, miR-19, miR-25, miR-34, miR-92, miR-93, miR-222, miR-149, miR-1977, miR-181b-2, miR-1259, and miR-1978. The nucleic acid molecule of claim 22, wherein the influenza virus coding sequence encodes an influenza virus protein selected from the group consisting of PBl, PB2, PA, Ml, M2, NP, NSl , and NS2/NEP. An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3' untranslated region (3' UTR) comprising one or more microRNA Response Element (MRE) sequences inserted between the stop codon of the transcript and the polyadenylation site.

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