Detail Information

Basic Information:


  VIRBase ID:  

HVID00005807

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-222-3p NS1
miRBase
Accession/Entrez ID		 MIMAT0000279 956533
Organism Homo sapiens Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Category miRNA mRNA
Alias - FLUAVs8gp2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-222-3p
rs1555936233 chrX:45747049    A/T
rs1555936234 chrX:45747051    G/T
rs1555936235 chrX:45747052    T/TTTA
rs1555936236 chrX:45747053    AGCTGC/A
rs782662324 chrX:45747050    T/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-222-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Gemcitabine-resistant cell line (A549-GR)|Gemcitabine-sensitive A549 parental cells (A549-P)     28743280
Exosome Plasma     30458449
Exosome BC cell lines (HCC70|MCF-7|MDA-MB-231)     30728048
Exosome Peripheral blood mononuclear cells     19002258
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast tissue|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-222-3p
Kikubasaponin 6712587 Drug sensitive
Lovastatin 53232 Drug sensitive
Vorinostat 5311 Drug resistant
Rustaiyan A 324967 Drug resistant
isatin dr - Drug resistant
tunicamycin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-222-3p
Oxaliplatine 6857599 Drug interaction    RC00002227
Fludarabine 657237 Drug interaction    RC00002224
Aniline 6115 Drug interaction    RC00002210
Atorvastatin 60823 Drug interaction    RC00002217
Gemcitabine 60750 Drug interaction    RC00002216
Progesterone 5994 Drug interaction    RC00002209
Vincristine 5978 Drug interaction    RC00002208
Estradiol 5757 Drug interaction    RC00002207
CID 56842234 56842234 Drug interaction    RC00002228
Sunitinib 5329102 Drug interaction    RC00004804
Eloxatine 5310940 Drug interaction    RC00002226
Raloxifene 5035 Drug interaction    RC00002206
Melphalan 460612 Drug interaction    RC00002223
Etoposide 36462 Drug interaction    RC00002215
Paclitaxel 36314 Drug interaction    RC00002214
5-Fluorouracil 3385 Drug interaction    RC00002205
Emodin 3220 Drug interaction    RC00004801
Emodin 3220 Drug interaction    RC00002204
Doxorubicin 31703 Drug interaction    RC00002213
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002203
Tamoxifen 2733526 Drug interaction    RC00002225
Nandrolone phenpropionate 229455 Drug interaction    RC00002222
Sorafenib 216239 Drug interaction    RC00002221
Arsenic trioxide 14888 Drug interaction    RC00002212
Docetaxel 148124 Drug interaction    RC00002220
Leucovorin 135403648 Drug interaction    RC00002229
Gefitinib 123631 Drug interaction    RC00002219
Androstanolone 10635 Drug interaction    RC00002211
Fulvestrant 104741 Drug interaction    RC00002218
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002231
Glucocorticoid - Drug interaction    RC00002232
Mistletoe lectin-I - Drug interaction    RC00002233
TRAIL therapy - Drug interaction    RC00002230
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-222-3p
Cisplatin 5702198       26676926
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-222-3p
Interactor2: NS1

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//RT-PCR
Support Database VIRmiRNA

References:


PMID WO_2010_101663_A2 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line A549 cells//HEK293T cells Interactor2 expression None
Description The nucleic acid molecule of claim 22 or 25, wherein the MRE corresponds to miRNA selected from the group consisting of miR-16, miR-17, miR-19, miR-25, miR-34, miR-92, miR-93, miR-222, miR-149, miR-1977, miR-181b-2, miR-1259, and miR-1978. The nucleic acid molecule of claim 22, wherein the influenza virus coding sequence encodes an influenza virus protein selected from the group consisting of PBl, PB2, PA, Ml, M2, NP, NSl , and NS2/NEP. An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3' untranslated region (3' UTR) comprising one or more microRNA Response Element (MRE) sequences inserted between the stop codon of the transcript and the polyadenylation site.

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