Detail Information

Basic Information:


  VIRBase ID:  

HVID00005799

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-181b-5p NS1
miRBase
Accession/Entrez ID		 MIMAT0000257 956533
Organism Homo sapiens Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Category miRNA mRNA
Alias - FLUAVs8gp2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-181b-5p
rs1205413123 chr1:198858926    C/A
rs1256400288 chr1:198858930    C/A
rs1264082334 chr1:198858938    A/C
rs1323404832 chr1:198858936    G/A
rs1385750980 chr1:198858937    C/T
rs1482775835 chr1:198858931    C/T
rs772751969 chr1:198858932    G/A
rs1351686016 chr9:124693736    C/T
rs1434920325 chr9:124693740    C/A
rs368826167 chr9:124693735    G/C
rs543189963 chr9:124693741    G/A
rs754985289 chr9:124693743    T/C
rs758726581 chr9:124693733    T/C
rs958593822 chr1:198858942    A/C
rs556757681 chr9:124693732    A/G
rs765712905 chr9:124693731    C/G
rs765712905 chr9:124693731    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-181b-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-181b-5p
Saintopin E 9864639 Drug sensitive
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive
2-Amino-3H-phenoxazin-3-one 72725 Drug resistant
2'-Bromo-4'-epi-daunorubicin 6711997 Drug sensitive
Fludarabine 657237 Drug sensitive
Psammaplin A 6400741 Drug sensitive
Bizelesin 60794 Drug sensitive
(Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive
Triethylenemelamine 5799 Drug sensitive
Mitomycin 5746 Drug sensitive
Vorinostat 5311 Drug sensitive
Dioxadet 48858 Drug sensitive
Epidoxoform 46877760 Drug sensitive
1,4-Benzoquinone 4650 Drug sensitive
Melphalan 460612 Drug sensitive
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive
Diaziquone 42616 Drug sensitive
Mitoxantrone 4212 Drug sensitive
3-Acetoxymethyl-1-methyl-5-methoxyindole-4,7-dione 404937 Drug resistant
N,N-Bis(2-chloropropyl)-N-methylammonium chloride 381678 Drug sensitive
Antineoplastic-D648114 372647 Drug sensitive
Antineoplastic-645804 371505 Drug resistant
Acridomide 364442 Drug sensitive
4-Aza-2'-phenyl-5alpha-cholestano[3,2-c]pyrazole 363170 Drug sensitive
6,7-Diacetoxyisoflavan 353129 Drug sensitive
Etoprine 29142 Drug resistant
Chlorambucil 2708 Drug sensitive
Deoxycamptothecin 266552 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
Camptothecin 24360 Drug sensitive
Dechlorinated rebeccamycin 24203043 Drug sensitive
Amsacrine 2179 Drug sensitive
N-(4-(1-Aziridinyl)butyl)-1,3-propanediamine 160395 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive
4-N,N-Bis(2-chloroethyl)amino-2-tolualdehyde 141295 Drug sensitive
N-[(1S,4R,7S,11R,14S,17R,20S,24R,27S)-2,4,12,15,17,25-Hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide 138402870 Drug sensitive
Oxanthrazole 135502299 Drug sensitive
5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive
8-Azaguanine 135403646 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Saintopin 131350 Drug sensitive
Cytochalasin q 11970174 Drug sensitive
Unii-6FH145297U 11541062 Drug sensitive
2,2'-Bioxirane 11254 Drug sensitive
Acetylenedicarboxamide 10971 Drug sensitive
Perillyl alcohol 10819 Drug sensitive
N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug sensitive
2,2'-thienyl selenophenyl-5',2-thiophene-5,5-dialdehyde - Drug resistant
naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug resistant
chlorazin - Drug resistant
ovb3-pe - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
cholestan-5.alpha.-ol-3,6-dione - Drug sensitive
analog of cc-1065 - Drug sensitive
Camptothecin Derivative - Drug sensitive
Chlorozotocin - Drug sensitive
from cephalodiscus gilchristi - Drug sensitive
hymenialdisine - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
potassium[trichloro(isopropylamine)platinum] - Drug sensitive
trans-dichlorobis(tricyclohexylphosphine)palladium - Drug sensitive
trimethyl(phenylthio)stannane - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-181b-5p
Curcumin 969516 Drug interaction    RC00001863
Formaldehyde 712 Drug interaction    RC00001843
Fludarabine 657237 Drug interaction    RC00001862
Cytarabine 6253 Drug interaction    RC00001850
Gemcitabine 60750 Drug interaction    RC00001854
Vincristine 5978 Drug interaction    RC00001849
Temozolomide 5394 Drug interaction    RC00001848
Eloxatine 5310940 Drug interaction    RC00001866
Imatinib 5291 Drug interaction    RC00001847
Morphine 5288826 Drug interaction    RC00001865
Teniposide 452548 Drug interaction    RC00001861
Tretinoin 444795 Drug interaction    RC00001860
Trichostatin A 444732 Drug interaction    RC00001859
Paclitaxel 36314 Drug interaction    RC00001853
Enoxacin 3229 Drug interaction    RC00001846
Doxorubicin 31703 Drug interaction    RC00001852
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001845
Tamoxifen 2733526 Drug interaction    RC00001864
Celecoxib 2662 Drug interaction    RC00001844
Sorafenib 216239 Drug interaction    RC00001858
Arsenic trioxide 14888 Drug interaction    RC00001851
Docetaxel 148124 Drug interaction    RC00001857
Gefitinib 123631 Drug interaction    RC00001856
Ginsenoside Rh2 119307 Drug interaction    RC00001855
modified ALLIC BFM 2002 protocol - Drug interaction    RC00001867
Aidi injection - Drug interaction    RC00001868
Marine fungal metabolite 1386A - Drug interaction    RC00001869
Olea europaea leaf extract - Drug interaction    RC00001870
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-181b-5p
Cisplatin 5702198       25356050
Temozolomide 5394       30551476
Paclitaxel 36314       26323677
Doxorubicin 31703       24759738
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-181b-5p
Interactor2: NS1

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//RT-PCR
Support Database VIRmiRNA

References:


PMID WO_2010_101663_A2 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line A549 cells//HEK293T cells Interactor2 expression None
Description The nucleic acid molecule of claim 22 or 25, wherein the MRE corresponds to miRNA selected from the group consisting of miR-16, miR-17, miR-19, miR-25, miR-34, miR-92, miR-93, miR-222, miR-149, miR-1977, miR-181b-2, miR-1259, and miR-1978. The nucleic acid molecule of claim 22, wherein the influenza virus coding sequence encodes an influenza virus protein selected from the group consisting of PBl, PB2, PA, Ml, M2, NP, NSl , and NS2/NEP. An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3' untranslated region (3' UTR) comprising one or more microRNA Response Element (MRE) sequences inserted between the stop codon of the transcript and the polyadenylation site.

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