Detail Information

Basic Information:


  VIRBase ID:  

HVID00005701

  Virus:  

Human betaherpesvirus 5 (HHV-5)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-221-3p UL122
miRBase
Accession/Entrez ID		 MIMAT0000278 3077563
Organism Homo sapiens Human betaherpesvirus 5 (HHV-5)
Category miRNA protein
Alias - HHV5wtgp107

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-221-3p
rs1555935979 chrX:45746180    G/A
rs1555935982 chrX:45746185    C/T

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-221-3p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Colorectal cancer cell lines (HCT-15|SW480|WiDr)     22895844
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast tissue|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-221-3p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
Mevastatin 64715 Drug sensitive
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
(3R,5S)-Fluvastatin(1-) 37888681 Drug sensitive
Gardenin A 261859 Drug sensitive
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug resistant
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug resistant
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug resistant
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug resistant
organosulfur compound - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive
atorvastatin calcium (usan) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-221-3p
Hyaluronidase 91820602 Drug interaction    RC00002198
Oxaliplatine 6857599 Drug interaction    RC00002196
Fludarabine 657237 Drug interaction    RC00002189
Aniline 6115 Drug interaction    RC00002170
Capecitabine 60953 Drug interaction    RC00002179
Atorvastatin 60823 Drug interaction    RC00002178
Gemcitabine 60750 Drug interaction    RC00002177
Vincristine 5978 Drug interaction    RC00002169
Dexamethasone 5743 Drug interaction    RC00002168
CID 56842234 56842234 Drug interaction    RC00002197
Simvastatin 54454 Drug interaction    RC00002176
Temozolomide 5394 Drug interaction    RC00002167
Sunitinib 5329102 Drug interaction    RC00002195
Eloxatine 5310940 Drug interaction    RC00002194
Morphine 5288826 Drug interaction    RC00002193
Cholecalciferol 5280795 Drug interaction    RC00002192
Melphalan 460612 Drug interaction    RC00002188
Docosahexaenoic acid 445580 Drug interaction    RC00002187
Trichostatin A 444732 Drug interaction    RC00002186
Metformin 4091 Drug interaction    RC00002166
Paclitaxel 36314 Drug interaction    RC00002175
5-Fluorouracil 3385 Drug interaction    RC00002165
Emodin 3220 Drug interaction    RC00002164
Doxorubicin 31703 Drug interaction    RC00002174
Lithium 3028194 Drug interaction    RC00002191
Lithium ion 28486 Drug interaction    RC00002173
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002163
Tamoxifen 2733526 Drug interaction    RC00002190
Carmustine 2578 Drug interaction    RC00002162
Verapamil 2520 Drug interaction    RC00002161
Nandrolone phenpropionate 229455 Drug interaction    RC00002185
Lapatinib 208908 Drug interaction    RC00002184
Arsenic trioxide 14888 Drug interaction    RC00002172
Docetaxel 148124 Drug interaction    RC00002183
Leucovorin 135403648 Drug interaction    RC00002199
Gefitinib 123631 Drug interaction    RC00002182
Ginsenoside Rh2 119307 Drug interaction    RC00002181
Androstanolone 10635 Drug interaction    RC00002171
Fulvestrant 104741 Drug interaction    RC00002180
AED therapy - Drug interaction    RC00002200
TRAIL therapy - Drug interaction    RC00002201
Trastuzumab - Drug interaction    RC00002202
Chemotherapy - Drug interaction    RC00008837
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-221-3p
5-Fluorouracil 3385       27726102

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-221-3p
Interactor2: UL122

Evidence Support:


Strong-Evidence Western blot
Support Database ViRBase

References:


PMID 31550968 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Neural precursor cells Interactor2 expression Downregulation
Description MiR-221 mimics transfection decreased the expression of IE2, pp65 and IE1, while miR-221 inhibitor transfection led to increased expression of IE2, pp65 and IE1 (Figure 2(G,H)). Together, these data draw a conclusion that miR-221 could attenuate the replication of HCMV in NPCs.

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