Detail Information

Basic Information:


  VIRBase ID:  

HVID00005613

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9975

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol gga-miR-21-5p MDV076
miRBase
Accession/Entrez ID		 MIMAT0003774 4811549
Organism Gallus gallus Gallid alphaherpesvirus 2
Category miRNA protein
Alias - GaHV2Md5_gp076//MD5V_076

Interaction Network (The top 100 interactions):


Interactor1: gga-miR-21-5p
Interactor2: MDV076

Evidence Support:


Strong-Evidence 5'-RACE//ChIP//Luciferase reporter assay//qRT-PCR//RT-PCR//Western blot
Support Database ViRBase

References:


PMID 23055556 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line DT-40 cells//JBJ-1 cells//MSB-1 cells//PA9 cells Interactor2 expression None
Description Finally, gga-miR-21 was overexpressed only during infection with a very virulent strain(RB-1B) and not during infection with a nononcogenic strain(CVI988), providing further evidence for its role in GaHV-2 lymphomagenesis. Our data therefore suggest an additional role for Meq in GaHV-2-mediated lymphomagenesis through the induction of miR-21 expression.

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