Detail Information

Basic Information:


  VIRBase ID:  

HVID00005509

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-143-3p X
miRBase
Accession/Entrez ID		 MIMAT0000435 944566
Organism Homo sapiens Hepatitis B virus (HBV)
Category miRNA protein
Alias - HBVgp3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-143-3p
rs1275333653 chr5:149428986    A/G
rs746434694 chr5:149428990    C/T
rs867385739 chr5:149428984    G/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-143-3p
Cytoplasm Luminal cells|Stromal cells     29073169
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Serum     25349172
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells|Saliva     -
Extracellular vesicle Human umbilical vein endothelial cells     22327366
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Nucleus Stromal cells     29073169

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-143-3p
Hyaluronidase 91820602 Drug interaction    RC00002874
Oxaliplatine 6857599 Drug interaction    RC00002872
Irinotecan 60838 Drug interaction    RC00002859
Gemcitabine 60750 Drug interaction    RC00002858
Estradiol 5757 Drug interaction    RC00002852
Temozolomide 5394 Drug interaction    RC00002851
Eloxatine 5310940 Drug interaction    RC00002871
Imatinib 5291 Drug interaction    RC00002850
Genistein 5280961 Drug interaction    RC00002870
Dinoprostone 5280360 Drug interaction    RC00002869
Quercetin 5280343 Drug interaction    RC00002868
Sodium butyrate 5222465 Drug interaction    RC00002867
Propofol 4943 Drug interaction    RC00002849
2-{[2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 46843772 Drug interaction    RC00002873
Decitabine 451668 Drug interaction    RC00002866
Docosahexaenoic acid 445580 Drug interaction    RC00002865
Trichostatin A 444732 Drug interaction    RC00002864
Ribavirin 37542 Drug interaction    RC00002857
Paclitaxel 36314 Drug interaction    RC00002856
5-Fluorouracil 3385 Drug interaction    RC00002848
Enoxacin 3229 Drug interaction    RC00002847
Doxorubicin 31703 Drug interaction    RC00002855
Ursodeoxycholic acid 31401 Drug interaction    RC00002854
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002846
Verapamil 2520 Drug interaction    RC00002845
Lenalidomide 216326 Drug interaction    RC00002863
Arsenic trioxide 14888 Drug interaction    RC00002853
Docetaxel 148124 Drug interaction    RC00002862
Geneticin 123865 Drug interaction    RC00002861
Gefitinib 123631 Drug interaction    RC00002860
Peginterferon alfa-2b - Drug interaction    RC00002875
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002876
Estrogen - Drug interaction    RC00002877
Medpor - Drug interaction    RC00002878
Chemotherapy - Drug interaction    RC00008845
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-143-3p
Paclitaxel 36314       30275853

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-143-3p
Interactor2: X

Evidence Support:


Strong-Evidence ChIP//Luciferase reporter assay//qRT-PCR//Western blot
Support Database ViRBase

References:


[1]PMID 19472311 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HepG2 cells//Huh7 cells Interactor2 expression None
Description As shown in Fig. 2C and 2D, trans-fection of HBx dramatically enhanced invasive activity compared with the EGFP vector group. Remarkably, the invasion of HBx-expressing cells was markedly inhibited by the transfection of miR-143 AS, whereas migration was not altered significantly in cells that were cotrans-fected with mock AS.
[2]PMID 23108868 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HepG2 cells//Huh7 cells Interactor2 expression None
Description MiR-143 overexpression in HBx-transfected cells significantly promotes cell migration with no substantial effect on cell proliferation or apoptosis,Thesedata indicate that miR-143 eases HBx-controlled cell migration/invasion both in vitro and in vivo.

Starting a new search, please wait ...