Detail Information

Basic Information:


  VIRBase ID:  

HVID00005502

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7g-5p X
miRBase
Accession/Entrez ID		 MIMAT0000414 944566
Organism Homo sapiens Hepatitis B virus (HBV)
Category miRNA protein
Alias - HBVgp3

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7g-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Epidermal melanocytes (HEMa-LP)|Malignant melanoma cell line (A375)     23056502
Exosome Saliva     23302638
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686
Mitochondrion HEK-293 cells|HeLa cells|Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7g-5p
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7g-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00002386
Formaldehyde 712 Drug interaction    RC00002374
Oxaliplatine 6857599 Drug interaction    RC00002388
Bisphenol A 6623 Drug interaction    RC00002379
Estradiol 5757 Drug interaction    RC00002378
Decitabine 451668 Drug interaction    RC00002387
Carboplatinum 38904 Drug interaction    RC00002385
Etoposide 36462 Drug interaction    RC00002384
Paclitaxel 36314 Drug interaction    RC00002383
5-Fluorouracil 3385 Drug interaction    RC00002377
Doxorubicin 31703 Drug interaction    RC00002382
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002376
Verapamil 2520 Drug interaction    RC00002375
Arsenic trioxide 14888 Drug interaction    RC00002381
Leucovorin 135403648 Drug interaction    RC00002389
Vinblastine 13342 Drug interaction    RC00002380
modified ALLIC BFM 2002 protocol - Drug interaction    RC00002390
Marine fungal metabolite 1386A - Drug interaction    RC00002391
Chemotherapy - Drug interaction    RC00008839
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7g-5p
Paclitaxel 36314       26323677
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7g-5p
Interactor2: X

Evidence Support:


Strong-Evidence qPCR//Western blot
Weak-Evidence Microarray
Support Database ViRBase

References:


[1]PMID 20447714 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HepG2 cells Interactor2 expression None
Description Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1. 5 andp-value of less than 0. 01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells .
[2]PMID 22425745 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HepG2 cells Interactor2 expression None
Description The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay.

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