Basic Information:
VIRBase ID: HVID00005501
Virus: Hepatitis B virus (HBV)
Host: Homo sapiens
Confidence Score: 0.9026
Interaction Type: Host-Virus interaction
Interactor Information:
Interactor1
Interactor2
Symbol
hsa-let-7g-5p
preS2
miRBase Accession/Entrez ID
MIMAT0000414
preS2
Organism
Homo sapiens
Hepatitis B virus (HBV)
Category
miRNA
mRNA
Alias
-
-
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
hsa-let-7g-5p
Related Drug Information:
Resource
Symbol
Drug Name
PubChem ID
Function
ncDR
hsa-let-7g-5p
Resource
Symbol
Drug Name
PubChem ID
Function
Link
RNAInter
hsa-let-7g-5p
Resource
Symbol
Drug Name
PubChem ID
PMID
NoncoRNA
hsa-let-7g-5p
Interaction Network (The top 100 interactions) :
Interactor1: hsa-let-7g-5p
Interactor2: preS2
Evidence Support:
Strong-Evidence
Dual luciferase reporter assay//Western blot
Prediction-Evidence
miRanda
Support Database
ViRBase
References:
PMID
26979389
Target region
None
Source
ViRBase
Interactor1 expression
None
Tissue or cell line
Hep38.7-tet cells
Interactor2 expression
Downregulation
Description
Here, we show that HBV mRNA in the preS2 region can be targeted by host miRNA let-7g. This leads to the sequestration of let-7g and inhibition of let-7g function.PreS2 mRNA is targeted by let-7 g.