Detail Information

Basic Information:


  VIRBase ID:  

HVID00005488

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-98-5p X
miRBase
Accession/Entrez ID		 MIMAT0000096 944566
Organism Homo sapiens Hepatitis B virus (HBV)
Category miRNA protein
Alias - HBVgp3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-98-5p
rs1357591935 chrX:53556304    T/C
rs1556934729 chrX:53556307    A/G
rs1556934737 chrX:53556311    T/G
rs1556934741 chrX:53556316    C/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-98-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B lymphoblastoid cells|Endothelial cells|Epithelial cells|Mast cells|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-98-5p
Thapsia villosa compd 5477211 Drug sensitive
Rogiolol 402519 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
2-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)-1h-imidazole - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
ellipticine, 6-(3-aminopropyl)-, dihydrochloride - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-98-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00001036
Curcumin 969516 Drug interaction    RC00001040
Formaldehyde 712 Drug interaction    RC00001027
Gemcitabine 60750 Drug interaction    RC00001034
Estradiol 5757 Drug interaction    RC00001031
Calcitriol 5280453 Drug interaction    RC00001041
5-Fluorouracil 3385 Drug interaction    RC00001030
Doxorubicin 31703 Drug interaction    RC00001033
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001029
Celecoxib 2662 Drug interaction    RC00001028
Lenalidomide 216326 Drug interaction    RC00001039
Arsenic trioxide 14888 Drug interaction    RC00001032
Docetaxel 148124 Drug interaction    RC00001038
Ginsenoside Rh2 119307 Drug interaction    RC00001037
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001043
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001042
Trastuzumab - Drug interaction    RC00001045
LPS - Drug interaction    RC00001044
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-98-5p
Cisplatin 5702198       27270317

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-98-5p
Interactor2: X

Evidence Support:


Strong-Evidence qPCR//Western blot
Weak-Evidence Microarray
Support Database ViRBase

References:


[1]PMID 20447714 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HepG2 cells Interactor2 expression None
Description Significantly differentially expressed miRNAs were identified as absolute mean fold change of greater than 1. 5 andp-value of less than 0. 01, and located in the two upper-lateral quadrants. Seven miRNAs (miR-30c, miR-193b, miR-342, miR-199a, miR-125a, miR-99b, and miR-191) were found to be significantly up-regulated while 11 miRNAs (miR-196a, miR-106a, miR-20a, and let-7 family of miRNAs) were found to be significantly down-regulated in HBx-expressing cells compared to the controlcells .
[2]PMID 22425745 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HepG2 cells Interactor2 expression None
Description The mechanism by which HBV regulates cellular miRNAs is largely unknown. One possible way is through HBV x protein(HBx). HBx plays a key role in regulating HBV replication and hepatocarcinogenesis. It upregulates 7(miR-30c, -99b, -125a, -191, -193b, -199a, -342) and down-regulates 11(let-7a, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, miR-20a, -98, -106a, -196a) miRNAs in the HBx-transfected HepG2 cells in a microarray assay.

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