Detail Information

Basic Information:


  VIRBase ID:  

HVID00005487

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-31-5p C
miRBase
Accession/Entrez ID		 MIMAT0000089 944568
Organism Homo sapiens Hepatitis B virus (HBV)
Category miRNA mRNA
Alias - HBVgp4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-31-5p
rs368583676 chr9:21512165    C/T
rs1475828657 chr9:21512176    C/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-31-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     29492481
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Endothelial cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-31-5p
Midostaurin 9829523 Drug sensitive
Dichlorodipropylstannane 93562 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive
(Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug resistant
Erioflorin acetate 5281443 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug sensitive
2,5-Bis(3-Amino-2,4,6-trinitrophenyl)-1,3,4-thiadiazole 385374 Drug resistant
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
Girolline 362388 Drug sensitive
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug resistant
Inosine dialdehyde 135400916 Drug resistant
Melampodinin 11953936 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug sensitive
7h-5,6-dithioleno[4,3-d]uracil - Drug resistant
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug resistant
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug resistant
5-hydroxyamino camptothecin - Drug resistant
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug sensitive
antineoplastic-d655481 - Drug sensitive
tp4ek - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-31-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00000917
Gemcitabine 60750 Drug interaction    RC00000916
Vincristine 5978 Drug interaction    RC00000910
Sunitinib 5329102 Drug interaction    RC00000925
Vorinostat 5311 Drug interaction    RC00000924
Eloxatine 5310940 Drug interaction    RC00000923
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate 5280427 Drug interaction    RC00000922
Decitabine 451668 Drug interaction    RC00000921
Trichostatin A 444732 Drug interaction    RC00000920
Staurosporine 44259 Drug interaction    RC00000915
Etoposide 36462 Drug interaction    RC00000914
Paclitaxel 36314 Drug interaction    RC00000913
5-Fluorouracil 3385 Drug interaction    RC00000909
Enoxacin 3229 Drug interaction    RC00000908
Doxorubicin 31703 Drug interaction    RC00000912
Valproic acid 3121 Drug interaction    RC00000907
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000906
Verapamil 2520 Drug interaction    RC00000905
Calcium sulfate 24497 Drug interaction    RC00000911
Docetaxel 148124 Drug interaction    RC00000919
Gefitinib 123631 Drug interaction    RC00000918
Succinic acid 1110 Drug interaction    RC00000904
platinum-based doublet chemotherapy - Drug interaction    RC00000926
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000927
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-31-5p
Oxaliplatin 9887053       30400960
Cisplatin 5702198       25356050
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-31-5p
Interactor2: C

Evidence Support:


Strong-Evidence Luciferase reporter assay
Support Database VIRmiRNA

References:


PMID 18431360 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7 cells Interactor2 expression None
Description Initially, in order to assess efficacy against HBV in vitro, Huh7 cells were co-transfected with miR-31/5- and miR-122/5-expressing vectors together with the pCH-9/3091 HBV replication competent target plasmid 21(Figure 2a).

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