Detail Information

Basic Information:


  VIRBase ID:  

HVID00005464

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol HULC C
miRBase
Accession/Entrez ID		 728655 944568
Organism Homo sapiens Hepatitis B virus (HBV)
Category lncRNA mRNA
Alias HCCAT1//LINC00078//NCRNA00078 HBVgp4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 HULC
rs7763881 chr6:8653014 A/C         21042317
rs2038540 chr6:8652438 C/G         21355061
rs1328868 chr6:8652345 A/G         23297363

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HULC
chr6:8652492-8652493(+) m6A exon       27773535
chr6:8652566-8652567(+) m6A exon       27773535
chr6:8652571-8652572(+) m6A exon       27773535
chr6:8652582-8652583(+) m6A exon       27773535
chr6:8652595-8652596(+) m6A exon       27773535
chr6:8652612-8652613(+) m6A exon       27773535
chr6:8653802-8653803(+) m6A exon       27773535
chr6:8653838-8653839(+) m6A exon       27773535
chr6:8653847-8653848(+) m6A exon       27773535
chr6:8653852-8653853(+) m6A exon       27773535
chr6:8653891-8653892(+) m6A exon       27773535
chr6:8653918-8653919(+) m6A exon       27773535
chr6:8654019-8654020(+) m6A exon       27773535
chr6:8654025-8654026(+) m6A exon       27773535
chr6:8654036-8654037(+) m6A exon       27773535
chr6:8654041-8654042(+) m6A exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate HULC
Cytoplasm Hepatoma cells     17241883
Exosome Serum     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug HULC
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
Panobinostat       6918837
Temsirolimus       6918289
Daporinad       6914657
Tanespimycin       6505803
Cytarabine       6253
Irinotecan       60838
Topotecan       60700
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
l-685,458       5479543
Austocystin D       5470400
Mito-tempol       54613387
N-[(3S,10R,13S,17S)-10,13-Dimethyl-17-[1-(methylamino)ethyl]-4-oxo-1,2,3,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-yl]-3-methylbut-2-enamide       54612859
Temozolomide       5394
Palbociclib       5330286
Vorinostat       5311
Alsterpaullone       5005498
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
Refametinib       44182295
Foretinib       42642645
Sporanox       3793
Paclitaxel       36314
5-Fluorouracil       3385
Elesclomol       300471
AT 116, benzylamine salt       282523
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Navitoclax       24978538
Quizartinib       24889392
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Arenaemycin E       24199350
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Nutlin-3       216345
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Docetaxel       148124
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone       135440466
Dovitinib       135398510
Akt inhibitor VIII       135398501
Methotrexate       126941
Lestaurtinib       126565
Gefitinib       123631
Dactolisib       11977753
Veliparib       11960529
BAY 61-3606 dihydrochloride       11784504
Trametinib       11707110
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Crizotinib       11626560
Pararosaniline hydrochloride       11292
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
Setoglaucine       107404
7-Ethyl-10-hydroxycamptothecin       104842
Pha-665752       10461815
VX-702       10341154
Afatinib       10184653
;9-benzyl-7-benzyloxy-2-benzyl-1-methyl-9H-carbolinium b...       -
Basic Fuchsin       -
Bleomycin (50 uM)       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
pararosaniline pamoate       -
TL-2-105       -
WZ3105       -
XMD14-99       -

Interaction Network (The top 100 interactions):


Interactor1: HULC
Interactor2: C

Evidence Support:


Strong-Evidence ELISA//qPCR//RT-PCR
Support Database ViRBase

References:


PMID 30981758 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HepAD38 cells//HepG2.2.15 cells Interactor2 expression None
Description Interestingly, ELISA, RT-qPCR and qPCR assays indicated that the upregulation of HULC increased the levels of HBeAg, HBsAg, pgRNA, HBx and HBV DNA in HepG2-PCH9/3091 cells (Fig. 1A and Supplementary Fig. S1H-I).

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